DICER1 Chromosome 14
Dicer 1, ribonuclease III
Upload your DNA to see your personal genotypes for variants in DICER1.
What This Gene Does
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2021]
Gene Info
Gene Group
"Endoribonucleases|MicroRNA protein coding host genes|RISC loading complex subunits"
Locus Type
gene with protein product
Location
14q32.13
Ensembl
ENSG00000100697
Associated Conditions (37)
DICER1-related tumor predisposition
Hereditary cancer-predisposing syndrome
Pleuropulmonary blastoma
Euthyroid goiter
Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome
Rhabdomyosarcoma
embryonal
2
Ovarian cancer
DICER1-related disorder
Breast neoplasm
Primary intracranial sarcoma
DICER1-mutant
Sertoli-Leydig cell tumor
Follicular thyroid carcinoma
Papillary thyroid carcinoma
Cancer or benign tumor
Sarcoma
Pediatric high-grade glioma
Ovarian serous cystadenocarcinoma
+17 more conditions
Key Variants
RS1024226278
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1032236740
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Pleuropulmonary blastoma, Euthyroid goiter
Health Risk
RS1045097916
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1047347414
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503601
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503614
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Ovarian cancer
Health Risk
RS1060503616
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503631
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503632
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503647
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503649
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related disorder
Health Risk
RS1060503652
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome
Health Risk
All Variants (929)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1893193729 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1893200825 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1893201715 | Health Risk | Pathogenic | — |
| RS1893206922 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1893209726 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1893210489 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1893211484 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1893214804 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1893215622 | Health Risk | Pathogenic | — |
| RS1893219311 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1893239532 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1893252120 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1893253451 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1893478668 | Health Risk | Pathogenic | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1893496450 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1893759823 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1893775878 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1893835509 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1893958393 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1893959823 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome |
| RS1894049306 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1894119538 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1894120957 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2139775781 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS2139811410 | Health Risk | Pathogenic | Rhabdomyosarcoma, embryonal, 2 |
| RS2139811427 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2139812177 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2139813178 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2139814525 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2139837979 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2139838411 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2139842363 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2139843944 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2139844470 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2139844761 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2139847738 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2139848275 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2139848791 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2139849146 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2139849996 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2139850703 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2139852861 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2139900809 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2139955381 | Health Risk | Pathogenic | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS2139958739 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2139962772 | Health Risk | Pathogenic | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS2139963605 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2139966575 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2139985474 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2139986793 | Health Risk | Pathogenic | — |