RELN Chromosome 7

Reelin
404 variants 404 Health Risk

Upload your DNA to see your personal genotypes for variants in RELN.

What This Gene Does
This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Associated Conditions (15)
Norman-Roberts syndrome
Familial temporal lobe epilepsy 7
Epilepsy
familial temporal lobe
1
Inborn genetic diseases
RELN-related disorder
Self-limited epilepsy with centrotemporal spikes
Intellectual disability
See cases
Neurodevelopmental delay
Seizure
Lissencephaly
Familial cancer of breast
9 conditions
Key Variants
RS113498433
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
Health Risk
RS113998363
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
Health Risk
RS114190729
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Epilepsy
Health Risk
RS114344654
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
Health Risk
RS114389730
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
Health Risk
RS114446781
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
Health Risk
RS114501042
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, RELN-related disorder
Health Risk
RS114577182
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Inborn genetic diseases
Health Risk
RS114620008
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
Health Risk
RS114620403
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
Health Risk
RS114647348
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, RELN-related disorder
Health Risk
RS114993407
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Epilepsy
Health Risk
All Variants (404)
RSID Category Clinical Significance Conditions
RS762369288 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Inborn genetic diseases
RS763717800 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS764121311 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS764185528 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Inborn genetic diseases
RS764488118 Health Risk Conflicting classifications of pathogenicity Familial temporal lobe epilepsy 7, Norman-Roberts syndrome, Familial temporal lobe epilepsy 7
RS764681189 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, RELN-related disorder
RS765151646 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Epilepsy
RS765261158 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS765274194 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS765511963 Health Risk Conflicting classifications of pathogenicity Inborn genetic diseases, Norman-Roberts syndrome, Familial temporal lobe epilepsy 7
RS765957925 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS766349515 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS766384576 Health Risk Conflicting classifications of pathogenicity Inborn genetic diseases, Norman-Roberts syndrome, Familial temporal lobe epilepsy 7
RS766701326 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS766824018 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS766869538 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS768054802 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Epilepsy
RS768731886 Health Risk Conflicting classifications of pathogenicity Inborn genetic diseases, Norman-Roberts syndrome, Familial temporal lobe epilepsy 7
RS768836895 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Inborn genetic diseases
RS768851752 Health Risk Conflicting classifications of pathogenicity Familial temporal lobe epilepsy 7, Norman-Roberts syndrome, Familial temporal lobe epilepsy 7
RS770064368 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS770503009 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS770657475 Health Risk Conflicting classifications of pathogenicity Familial temporal lobe epilepsy 7, Norman-Roberts syndrome, Familial temporal lobe epilepsy 7
RS770986138 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS771172788 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS771804551 Health Risk Conflicting classifications of pathogenicity Familial temporal lobe epilepsy 7, Norman-Roberts syndrome, Familial temporal lobe epilepsy 7
RS772573526 Health Risk Conflicting classifications of pathogenicity Familial temporal lobe epilepsy 7, Norman-Roberts syndrome, Familial temporal lobe epilepsy 7
RS772745844 Health Risk Conflicting classifications of pathogenicity Inborn genetic diseases, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS773149531 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Inborn genetic diseases
RS773262289 Health Risk Conflicting classifications of pathogenicity Familial temporal lobe epilepsy 7, Norman-Roberts syndrome, Inborn genetic diseases
RS773589573 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Epilepsy
RS773832988 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS774202843 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS775529885 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS776781331 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS776886354 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS777083831 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS777197865 Health Risk Conflicting classifications of pathogenicity Familial temporal lobe epilepsy 7, Norman-Roberts syndrome, Familial temporal lobe epilepsy 7
RS777543027 Health Risk Conflicting classifications of pathogenicity Familial temporal lobe epilepsy 7, Norman-Roberts syndrome, Familial temporal lobe epilepsy 7
RS777581847 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Inborn genetic diseases
RS777784662 Health Risk Conflicting classifications of pathogenicity Familial temporal lobe epilepsy 7, Norman-Roberts syndrome, Familial temporal lobe epilepsy 7
RS778861276 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Inborn genetic diseases
RS779007436 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS779014769 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Inborn genetic diseases
RS779530655 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Inborn genetic diseases
RS779803541 Health Risk Conflicting classifications of pathogenicity Familial temporal lobe epilepsy 7, Norman-Roberts syndrome, Familial temporal lobe epilepsy 7
RS780325204 Health Risk Conflicting classifications of pathogenicity Familial temporal lobe epilepsy 7, Norman-Roberts syndrome, Inborn genetic diseases
RS780392692 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Inborn genetic diseases
RS78480723 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Inborn genetic diseases
RS79161241 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, RELN-related disorder
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