RELN Chromosome 7

Reelin
404 variants 404 Health Risk

Upload your DNA to see your personal genotypes for variants in RELN.

What This Gene Does
This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Associated Conditions (15)
Norman-Roberts syndrome
Familial temporal lobe epilepsy 7
Epilepsy
familial temporal lobe
1
Inborn genetic diseases
RELN-related disorder
Self-limited epilepsy with centrotemporal spikes
Intellectual disability
See cases
Neurodevelopmental delay
Seizure
Lissencephaly
Familial cancer of breast
9 conditions
Key Variants
RS113498433
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
Health Risk
RS113998363
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
Health Risk
RS114190729
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Epilepsy
Health Risk
RS114344654
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
Health Risk
RS114389730
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
Health Risk
RS114446781
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
Health Risk
RS114501042
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, RELN-related disorder
Health Risk
RS114577182
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Inborn genetic diseases
Health Risk
RS114620008
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
Health Risk
RS114620403
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
Health Risk
RS114647348
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, RELN-related disorder
Health Risk
RS114993407
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Epilepsy
Health Risk
All Variants (404)
RSID Category Clinical Significance Conditions
RS587780438 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS587780439 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Epilepsy
RS727504126 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, RELN-related disorder
RS73714410 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Inborn genetic diseases
RS746451678 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS746613525 Health Risk Conflicting classifications of pathogenicity Familial temporal lobe epilepsy 7, Norman-Roberts syndrome, Familial temporal lobe epilepsy 7
RS747512816 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS747527621 Health Risk Conflicting classifications of pathogenicity Familial temporal lobe epilepsy 7, Norman-Roberts syndrome, Inborn genetic diseases
RS747571208 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS748901010 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Inborn genetic diseases
RS748927848 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS748936767 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS749580328 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS750252271 Health Risk Conflicting classifications of pathogenicity Familial temporal lobe epilepsy 7, Norman-Roberts syndrome, Inborn genetic diseases
RS750386872 Health Risk Conflicting classifications of pathogenicity Inborn genetic diseases, Norman-Roberts syndrome, Familial temporal lobe epilepsy 7
RS750621529 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS751431158 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS751859147 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS752081680 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS752208462 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS752238353 Health Risk Conflicting classifications of pathogenicity Familial temporal lobe epilepsy 7, Norman-Roberts syndrome, Familial temporal lobe epilepsy 7
RS752566456 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS753289916 Health Risk Conflicting classifications of pathogenicity Familial temporal lobe epilepsy 7, Norman-Roberts syndrome, Familial temporal lobe epilepsy 7
RS753376558 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS753769576 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS753782715 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Inborn genetic diseases
RS754156411 Health Risk Conflicting classifications of pathogenicity Familial temporal lobe epilepsy 7, Norman-Roberts syndrome, Inborn genetic diseases
RS754915287 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS755465811 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS755596079 Health Risk Conflicting classifications of pathogenicity Familial temporal lobe epilepsy 7, Norman-Roberts syndrome, Epilepsy
RS755634872 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS755660948 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Inborn genetic diseases
RS755797350 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, RELN-related disorder
RS756018749 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS756193988 Health Risk Conflicting classifications of pathogenicity Familial temporal lobe epilepsy 7, Norman-Roberts syndrome, Inborn genetic diseases
RS756988903 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS757003273 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS757357348 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS757568270 Health Risk Conflicting classifications of pathogenicity Inborn genetic diseases, Norman-Roberts syndrome, Familial temporal lobe epilepsy 7
RS757726526 Health Risk Conflicting classifications of pathogenicity Familial temporal lobe epilepsy 7, Norman-Roberts syndrome, Epilepsy
RS757915171 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Inborn genetic diseases
RS758485261 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS758505618 Health Risk Conflicting classifications of pathogenicity Familial temporal lobe epilepsy 7, Norman-Roberts syndrome, Familial temporal lobe epilepsy 7
RS758828226 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS758883183 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS759501468 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS760337154 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Inborn genetic diseases
RS760775607 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS761738403 Health Risk Conflicting classifications of pathogenicity Familial temporal lobe epilepsy 7, Norman-Roberts syndrome, Epilepsy
RS762015967 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Inborn genetic diseases
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