RELN Chromosome 7

Reelin
404 variants 404 Health Risk

Upload your DNA to see your personal genotypes for variants in RELN.

What This Gene Does
This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Associated Conditions (15)
Norman-Roberts syndrome
Familial temporal lobe epilepsy 7
Epilepsy
familial temporal lobe
1
Inborn genetic diseases
RELN-related disorder
Self-limited epilepsy with centrotemporal spikes
Intellectual disability
See cases
Neurodevelopmental delay
Seizure
Lissencephaly
Familial cancer of breast
9 conditions
Key Variants
RS113498433
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
Health Risk
RS113998363
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
Health Risk
RS114190729
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Epilepsy
Health Risk
RS114344654
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
Health Risk
RS114389730
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
Health Risk
RS114446781
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
Health Risk
RS114501042
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, RELN-related disorder
Health Risk
RS114577182
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Inborn genetic diseases
Health Risk
RS114620008
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
Health Risk
RS114620403
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
Health Risk
RS114647348
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, RELN-related disorder
Health Risk
RS114993407
Conflicting classifications of pathogenicity
Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Epilepsy
Health Risk
All Variants (404)
RSID Category Clinical Significance Conditions
RS371309082 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Inborn genetic diseases
RS371476408 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Inborn genetic diseases
RS371614773 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Inborn genetic diseases
RS372015884 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Epilepsy
RS372473867 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, RELN-related disorder
RS372887562 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS373730762 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Inborn genetic diseases
RS373969392 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS374088118 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS374232523 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Inborn genetic diseases
RS374546580 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Inborn genetic diseases
RS374927338 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS375118721 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, RELN-related disorder
RS375141725 Health Risk Conflicting classifications of pathogenicity Familial temporal lobe epilepsy 7, Norman-Roberts syndrome, Familial temporal lobe epilepsy 7
RS375230548 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, RELN-related disorder
RS375427974 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS375985673 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Epilepsy
RS376360223 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS377429197 Health Risk Conflicting classifications of pathogenicity Familial temporal lobe epilepsy 7, Norman-Roberts syndrome, RELN-related disorder
RS377549748 Health Risk Conflicting classifications of pathogenicity Familial temporal lobe epilepsy 7, Norman-Roberts syndrome, Inborn genetic diseases
RS377638585 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Epilepsy, familial temporal lobe
RS398124191 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS398124192 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS41275239 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, RELN-related disorder
RS41276145 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS529198383 Health Risk Conflicting classifications of pathogenicity Familial temporal lobe epilepsy 7, Norman-Roberts syndrome, Familial temporal lobe epilepsy 7
RS530120957 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS539045917 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS539337691 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS540271067 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, RELN-related disorder
RS542352292 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS544646610 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS544717229 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, RELN-related disorder
RS544906913 Health Risk Conflicting classifications of pathogenicity Familial temporal lobe epilepsy 7, Norman-Roberts syndrome, Familial temporal lobe epilepsy 7
RS549360134 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS554215103 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS555946635 Health Risk Conflicting classifications of pathogenicity Familial temporal lobe epilepsy 7, Norman-Roberts syndrome, Inborn genetic diseases
RS55656324 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS55693709 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS558308794 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Inborn genetic diseases
RS560704715 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS56146903 Health Risk Conflicting classifications of pathogenicity Familial temporal lobe epilepsy 7, Norman-Roberts syndrome, Epilepsy
RS561828305 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Inborn genetic diseases
RS56342240 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS565236668 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Inborn genetic diseases
RS565382144 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS566580675 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS567245963 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS568950079 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, Norman-Roberts syndrome
RS569919781 Health Risk Conflicting classifications of pathogenicity Norman-Roberts syndrome, Familial temporal lobe epilepsy 7, RELN-related disorder
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