PALB2 Chromosome 16
Partner and localizer of BRCA2
Upload your DNA to see your personal genotypes for variants in PALB2.
What This Gene Does
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"WD repeat domain containing|FA complementation groups"
Locus Type
gene with protein product
Location
16p12.2
Ensembl
ENSG00000083093
Associated Conditions (74)
Hereditary cancer-predisposing syndrome
Familial cancer of breast
PALB2-related cancer predisposition
Fanconi anemia complementation group N
Malignant tumor of breast
Carcinoma of colon
Pancreatic cancer
susceptibility to
3
Hereditary breast ovarian cancer syndrome
Breast-ovarian cancer
familial
5
PALB2-related disorder
Familial pancreatic carcinoma
Chordoma
Familial ovarian cancer
Sarcoma
Uterine corpus endometrial carcinoma
Acute myeloid leukemia
+54 more conditions
Key Variants
RS1031787378
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1038099508
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, PALB2-related cancer predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1055533509
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1056494105
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057517611
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520645
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520982
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N, Familial cancer of breast
Health Risk
RS1057520985
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1060499831
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast
Health Risk
RS1060502735
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast
Health Risk
RS1060502737
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
RS1060502739
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
All Variants (1758)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS537258442 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS541028076 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Carcinoma of colon |
| RS545119348 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Ovarian cancer |
| RS554849907 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, PALB2-related disorder |
| RS560853558 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast |
| RS566813395 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer |
| RS567706422 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Fanconi anemia complementation group N |
| RS570455216 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, PALB2-related disorder |
| RS571063157 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Breast-ovarian cancer |
| RS572102702 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer |
| RS573118236 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Breast-ovarian cancer |
| RS573744591 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS57605939 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS576081828 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS577006107 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS577651839 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Fanconi anemia complementation group N |
| RS577969558 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Pancreatic cancer |
| RS587776527 | Health Risk | Conflicting classifications of pathogenicity | Pancreatic cancer, susceptibility to, 3 |
| RS587778582 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Malignant tumor of breast |
| RS587778583 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS587778585 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS587778586 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS587778587 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N, Familial cancer of breast |
| RS587778588 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS587780205 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Pancreatic cancer |
| RS587780207 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS587780208 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS587780214 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Triple-negative breast cancer |
| RS587780216 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS587780220 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS587780221 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS587780222 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS587780223 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Fanconi anemia complementation group N |
| RS587780820 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Breast and/or ovarian cancer |
| RS587780821 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS587780822 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, PALB2-related disorder |
| RS587780823 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS587780824 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer |
| RS587781498 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS587781602 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS587781818 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Fanconi anemia complementation group N |
| RS587781824 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Fanconi anemia complementation group N |
| RS587781954 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Pancreatic cancer |
| RS587781975 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS587782050 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast |
| RS587782151 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Fanconi anemia complementation group N |
| RS587782164 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Fanconi anemia complementation group N |
| RS587782200 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS587782211 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS587782387 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial ovarian cancer |