PALB2 Chromosome 16
Partner and localizer of BRCA2
Upload your DNA to see your personal genotypes for variants in PALB2.
What This Gene Does
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"WD repeat domain containing|FA complementation groups"
Locus Type
gene with protein product
Location
16p12.2
Ensembl
ENSG00000083093
Associated Conditions (74)
Hereditary cancer-predisposing syndrome
Familial cancer of breast
PALB2-related cancer predisposition
Fanconi anemia complementation group N
Malignant tumor of breast
Carcinoma of colon
Pancreatic cancer
susceptibility to
3
Hereditary breast ovarian cancer syndrome
Breast-ovarian cancer
familial
5
PALB2-related disorder
Familial pancreatic carcinoma
Chordoma
Familial ovarian cancer
Sarcoma
Uterine corpus endometrial carcinoma
Acute myeloid leukemia
+54 more conditions
Key Variants
RS1031787378
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1038099508
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, PALB2-related cancer predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1055533509
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1056494105
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057517611
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520645
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520982
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N, Familial cancer of breast
Health Risk
RS1057520985
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1060499831
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast
Health Risk
RS1060502735
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast
Health Risk
RS1060502737
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
RS1060502739
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
All Variants (1758)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS769841151 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS769849072 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Fanconi anemia complementation group N |
| RS770145849 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS770908238 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS770965402 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Pilocytic astrocytoma |
| RS770996884 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS771002573 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast |
| RS771246748 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS771288520 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS771376636 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS771827859 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS771846754 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS772095244 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS773001248 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Pancreatic cancer |
| RS773340677 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Carcinoma of colon |
| RS773831304 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Malignant tumor of breast |
| RS774057025 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS774502617 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Malignant tumor of breast |
| RS774517454 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer |
| RS774949203 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, PALB2-related cancer predisposition |
| RS775193384 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Chordoma |
| RS776110440 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS776115183 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS776902295 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS777244673 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, PALB2-related disorder |
| RS778309339 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Carcinoma of colon |
| RS778573607 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS778602038 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer |
| RS778705498 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS778890869 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS779184831 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS780415750 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS780521904 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS780772404 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, PALB2-related cancer predisposition |
| RS781663559 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS786201088 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Fanconi anemia complementation group N |
| RS786201790 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS786201806 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS786202468 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS786202524 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Fanconi anemia complementation group N |
| RS786202550 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS786202692 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Breast and/or ovarian cancer |
| RS786202699 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Carcinoma of colon |
| RS786202850 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS786202943 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Pancreatic cancer |
| RS786203040 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Fanconi anemia complementation group N |
| RS786203164 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS786203176 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Fanconi anemia complementation group N |
| RS786203245 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Familial cancer of breast |
| RS786203246 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |