PALB2 Chromosome 16
Partner and localizer of BRCA2
Upload your DNA to see your personal genotypes for variants in PALB2.
What This Gene Does
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"WD repeat domain containing|FA complementation groups"
Locus Type
gene with protein product
Location
16p12.2
Ensembl
ENSG00000083093
Associated Conditions (74)
Hereditary cancer-predisposing syndrome
Familial cancer of breast
PALB2-related cancer predisposition
Fanconi anemia complementation group N
Malignant tumor of breast
Carcinoma of colon
Pancreatic cancer
susceptibility to
3
Hereditary breast ovarian cancer syndrome
Breast-ovarian cancer
familial
5
PALB2-related disorder
Familial pancreatic carcinoma
Chordoma
Familial ovarian cancer
Sarcoma
Uterine corpus endometrial carcinoma
Acute myeloid leukemia
+54 more conditions
Key Variants
RS1031787378
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1038099508
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, PALB2-related cancer predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1055533509
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1056494105
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057517611
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520645
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520982
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N, Familial cancer of breast
Health Risk
RS1057520985
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1060499831
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast
Health Risk
RS1060502735
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast
Health Risk
RS1060502737
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
RS1060502739
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
All Variants (1758)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS371627753 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS371875379 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N, Familial cancer of breast |
| RS373298267 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, PALB2-related disorder |
| RS373321719 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS373478248 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast |
| RS373483056 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Inherited breast cancer and ovarian cancer |
| RS373876101 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast |
| RS373970237 | Health Risk | Conflicting classifications of pathogenicity | Breast neoplasm, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS374090568 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS374425261 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS374707677 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS374736398 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Malignant tumor of breast |
| RS376619846 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Pancreatic cancer |
| RS376641234 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS377085677 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, PALB2-related disorder |
| RS377149139 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Malignant tumor of breast |
| RS377486858 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS377626805 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Fanconi anemia complementation group N |
| RS377713277 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS45447991 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Breast and/or ovarian cancer |
| RS45457297 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS45464500 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS45464991 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Pancreatic cancer |
| RS45478192 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS45486906 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS45505500 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Breast and/or ovarian cancer |
| RS45508997 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer |
| RS45510998 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary breast ovarian cancer syndrome |
| RS45537237 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial pancreatic carcinoma |
| RS45543843 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast |
| RS45548638 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Malignant tumor of breast |
| RS45551636 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS45561331 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Malignant tumor of breast |
| RS45585833 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS45594034 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer |
| RS45616636 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast |
| RS45619737 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Esophageal atresia/tracheoesophageal fistula |
| RS515726063 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Pancreatic cancer |
| RS515726072 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial ovarian cancer |
| RS515726085 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast |
| RS515726088 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Breast and/or ovarian cancer |
| RS515726094 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Inherited breast cancer and ovarian cancer |
| RS515726108 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS515726113 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS515726114 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Fanconi anemia complementation group N, Familial cancer of breast |
| RS515726116 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS515726125 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, PALB2-related cancer predisposition |
| RS515726130 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS528541334 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast |
| RS536644825 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |