PALB2 Chromosome 16
Partner and localizer of BRCA2
Upload your DNA to see your personal genotypes for variants in PALB2.
What This Gene Does
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"WD repeat domain containing|FA complementation groups"
Locus Type
gene with protein product
Location
16p12.2
Ensembl
ENSG00000083093
Associated Conditions (74)
Hereditary cancer-predisposing syndrome
Familial cancer of breast
PALB2-related cancer predisposition
Fanconi anemia complementation group N
Malignant tumor of breast
Carcinoma of colon
Pancreatic cancer
susceptibility to
3
Hereditary breast ovarian cancer syndrome
Breast-ovarian cancer
familial
5
PALB2-related disorder
Familial pancreatic carcinoma
Chordoma
Familial ovarian cancer
Sarcoma
Uterine corpus endometrial carcinoma
Acute myeloid leukemia
+54 more conditions
Key Variants
RS1031787378
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1038099508
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, PALB2-related cancer predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1055533509
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1056494105
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057517611
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520645
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520982
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N, Familial cancer of breast
Health Risk
RS1057520985
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1060499831
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast
Health Risk
RS1060502735
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast
Health Risk
RS1060502737
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
RS1060502739
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
All Variants (1758)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1555461432 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1555461435 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555461447 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1555461462 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555461474 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1555461531 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1555461584 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555461587 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1555461659 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555461779 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1555461809 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N, Familial cancer of breast |
| RS1555461835 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555461872 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1567206753 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1567212950 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Fanconi anemia complementation group N, Pancreatic cancer |
| RS1567214357 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1567214528 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1567215519 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1567215613 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1567216902 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS1567216906 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1567218311 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Fanconi anemia complementation group N |
| RS1567218614 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1567218624 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1567218910 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1567219034 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer |
| RS1567221020 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1567221490 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1567221497 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS1567221558 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1567221740 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1567221840 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Ovarian neoplasm, Hereditary cancer-predisposing syndrome |
| RS1567223015 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1567223045 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1597062059 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1597066812 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1597067067 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1597081224 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1597082876 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Familial cancer of breast |
| RS1597085400 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Familial cancer of breast |
| RS1597090787 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Familial cancer of breast |
| RS1597091217 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1597095450 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1597095457 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1597095559 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1597095773 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1597096071 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1597096898 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1597098223 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1597098858 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |