PALB2 Chromosome 16
Partner and localizer of BRCA2
Upload your DNA to see your personal genotypes for variants in PALB2.
What This Gene Does
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"WD repeat domain containing|FA complementation groups"
Locus Type
gene with protein product
Location
16p12.2
Ensembl
ENSG00000083093
Associated Conditions (74)
Hereditary cancer-predisposing syndrome
Familial cancer of breast
PALB2-related cancer predisposition
Fanconi anemia complementation group N
Malignant tumor of breast
Carcinoma of colon
Pancreatic cancer
susceptibility to
3
Hereditary breast ovarian cancer syndrome
Breast-ovarian cancer
familial
5
PALB2-related disorder
Familial pancreatic carcinoma
Chordoma
Familial ovarian cancer
Sarcoma
Uterine corpus endometrial carcinoma
Acute myeloid leukemia
+54 more conditions
Key Variants
RS1031787378
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1038099508
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, PALB2-related cancer predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1055533509
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1056494105
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057517611
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520645
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520982
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N, Familial cancer of breast
Health Risk
RS1057520985
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1060499831
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast
Health Risk
RS1060502735
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast
Health Risk
RS1060502737
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
RS1060502739
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
All Variants (1758)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1462734899 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS146377793 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary breast ovarian cancer syndrome |
| RS146434474 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Retinoblastoma |
| RS146455175 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1473991269 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1475548158 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS148026749 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast |
| RS148102335 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Pancreatic cancer |
| RS148335539 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Papillary thyroid carcinoma |
| RS148647206 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS1489345430 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, PALB2-related disorder |
| RS149194681 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Breast-ovarian cancer |
| RS149522412 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N, Familial cancer of breast |
| RS149836639 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Fanconi anemia complementation group N |
| RS150390726 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary breast ovarian cancer syndrome |
| RS150517167 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS150636811 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Inherited breast cancer and ovarian cancer |
| RS151316635 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS1555458809 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555459421 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555459513 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1555459583 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555459605 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1555459610 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555459710 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555459927 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1555459946 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1555460231 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555460308 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555460328 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1555460348 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555460440 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555460445 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Hereditary breast ovarian cancer syndrome, Familial cancer of breast |
| RS1555460514 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555460531 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555460565 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1555460652 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555460653 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555460705 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555461154 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Gastric cancer |
| RS1555461198 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1555461202 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555461218 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555461243 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1555461258 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer |
| RS1555461270 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1555461357 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555461376 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555461423 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555461427 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |