PALB2 Chromosome 16
Partner and localizer of BRCA2
Upload your DNA to see your personal genotypes for variants in PALB2.
What This Gene Does
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"WD repeat domain containing|FA complementation groups"
Locus Type
gene with protein product
Location
16p12.2
Ensembl
ENSG00000083093
Associated Conditions (74)
Hereditary cancer-predisposing syndrome
Familial cancer of breast
PALB2-related cancer predisposition
Fanconi anemia complementation group N
Malignant tumor of breast
Carcinoma of colon
Pancreatic cancer
susceptibility to
3
Hereditary breast ovarian cancer syndrome
Breast-ovarian cancer
familial
5
PALB2-related disorder
Familial pancreatic carcinoma
Chordoma
Familial ovarian cancer
Sarcoma
Uterine corpus endometrial carcinoma
Acute myeloid leukemia
+54 more conditions
Key Variants
RS1031787378
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1038099508
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, PALB2-related cancer predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1055533509
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1056494105
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057517611
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520645
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520982
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N, Familial cancer of breast
Health Risk
RS1057520985
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1060499831
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast
Health Risk
RS1060502735
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast
Health Risk
RS1060502737
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
RS1060502739
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
All Variants (1758)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS587776406 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS587776419 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS587776423 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS587776428 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Fanconi anemia complementation group N |
| RS587781457 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS587781662 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS587782443 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Pancreatic cancer |
| RS587782462 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary breast ovarian cancer syndrome |
| RS587782566 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary breast ovarian cancer syndrome |
| RS730881876 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary breast ovarian cancer syndrome |
| RS730881888 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer |
| RS750650768 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Fanconi anemia complementation group N |
| RS752513498 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS753153576 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary breast ovarian cancer syndrome |
| RS755263466 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Malignant tumor of breast, Hereditary cancer-predisposing syndrome |
| RS766394024 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary breast ovarian cancer syndrome |
| RS767633741 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, PALB2-related cancer predisposition |
| RS773829275 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Fanconi anemia complementation group N |
| RS786203488 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Fanconi anemia complementation group N |
| RS786203714 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Basal cell carcinoma, Generalized hypopigmentation |
| RS786203775 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Malignant tumor of breast |
| RS786203821 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary breast ovarian cancer syndrome |
| RS786203892 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Pancreatic cancer |
| RS864622138 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Breast-ovarian cancer, familial |
| RS864622192 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS864622301 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS864622481 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS864622498 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Pancreatic cancer |
| RS864622695 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS869312772 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS875989792 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS876658192 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Malignant tumor of breast |
| RS876658348 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Gastric cancer |
| RS876658983 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Breast and/or ovarian cancer |
| RS876659405 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS876659571 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Pancreatic cancer |
| RS876660475 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast |
| RS876660492 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS876660574 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS876660643 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS876660719 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS878855118 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS878855122 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast |
| RS879253892 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS879253960 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS879254113 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS879254121 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS879254197 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS886039480 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Fanconi anemia, Hereditary cancer |
| RS886039620 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Familial cancer of breast |