PALB2 Chromosome 16
Partner and localizer of BRCA2
Upload your DNA to see your personal genotypes for variants in PALB2.
What This Gene Does
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"WD repeat domain containing|FA complementation groups"
Locus Type
gene with protein product
Location
16p12.2
Ensembl
ENSG00000083093
Associated Conditions (74)
Hereditary cancer-predisposing syndrome
Familial cancer of breast
PALB2-related cancer predisposition
Fanconi anemia complementation group N
Malignant tumor of breast
Carcinoma of colon
Pancreatic cancer
susceptibility to
3
Hereditary breast ovarian cancer syndrome
Breast-ovarian cancer
familial
5
PALB2-related disorder
Familial pancreatic carcinoma
Chordoma
Familial ovarian cancer
Sarcoma
Uterine corpus endometrial carcinoma
Acute myeloid leukemia
+54 more conditions
Key Variants
RS1031787378
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1038099508
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, PALB2-related cancer predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1055533509
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1056494105
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057517611
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520645
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520982
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N, Familial cancer of breast
Health Risk
RS1057520985
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1060499831
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast
Health Risk
RS1060502735
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast
Health Risk
RS1060502737
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
RS1060502739
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
All Variants (1758)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1966798806 | Health Risk | Pathogenic/Likely pathogenic | Pancreatic cancer, susceptibility to, 3 |
| RS1966856604 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary breast ovarian cancer syndrome, Hereditary cancer-predisposing syndrome |
| RS1966862408 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1966863209 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1966964908 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1967027806 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1967055393 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1967057228 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1967112121 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N, Breast-ovarian cancer |
| RS2142252781 | Health Risk | Pathogenic/Likely pathogenic | Ovarian carcinoma, Breast and/or ovarian cancer, Familial cancer of breast |
| RS2142298948 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142367858 | Health Risk | Pathogenic/Likely pathogenic | Malignant tumor of breast, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2142374907 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2142380816 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142383242 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142389365 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2142422250 | Health Risk | Pathogenic/Likely pathogenic | Breast-ovarian cancer, familial, susceptibility to |
| RS2142431841 | Health Risk | Pathogenic/Likely pathogenic | Carcinoma of colon, Familial cancer of breast, Fanconi anemia complementation group N |
| RS2142436112 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142444897 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2142458017 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer |
| RS2142459705 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Familial cancer of breast, Familial cancer of breast |
| RS2142461082 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506196512 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2506196933 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2506197444 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506214884 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2506214923 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2506215298 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Breast and/or ovarian cancer, Familial cancer of breast |
| RS2506318271 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506320815 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506336959 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506396824 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506397575 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2506404426 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506412889 | Health Risk | Pathogenic/Likely pathogenic | Breast and/or ovarian cancer, Hereditary cancer-predisposing syndrome, Breast and/or ovarian cancer |
| RS2506413914 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, PALB2-related cancer predisposition, Familial cancer of breast |
| RS2506469663 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Inherited breast cancer and ovarian cancer |
| RS2506477651 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2506480988 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2506488340 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS2506492441 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS2506518601 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS2506540801 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS45494092 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS515726067 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary breast ovarian cancer syndrome |
| RS515726111 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS515726118 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS515726126 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary breast ovarian cancer syndrome |
| RS587776405 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Fanconi anemia complementation group N |