PALB2 Chromosome 16
Partner and localizer of BRCA2
Upload your DNA to see your personal genotypes for variants in PALB2.
What This Gene Does
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"WD repeat domain containing|FA complementation groups"
Locus Type
gene with protein product
Location
16p12.2
Ensembl
ENSG00000083093
Associated Conditions (74)
Hereditary cancer-predisposing syndrome
Familial cancer of breast
PALB2-related cancer predisposition
Fanconi anemia complementation group N
Malignant tumor of breast
Carcinoma of colon
Pancreatic cancer
susceptibility to
3
Hereditary breast ovarian cancer syndrome
Breast-ovarian cancer
familial
5
PALB2-related disorder
Familial pancreatic carcinoma
Chordoma
Familial ovarian cancer
Sarcoma
Uterine corpus endometrial carcinoma
Acute myeloid leukemia
+54 more conditions
Key Variants
RS1031787378
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1038099508
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, PALB2-related cancer predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1055533509
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1056494105
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057517611
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520645
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
Health Risk
RS1057520982
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N, Familial cancer of breast
Health Risk
RS1057520985
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome
Health Risk
RS1060499831
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast
Health Risk
RS1060502735
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Malignant tumor of breast
Health Risk
RS1060502737
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
RS1060502739
Conflicting classifications of pathogenicity
Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast
Health Risk
All Variants (1758)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1555461280 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555461358 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1555461366 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, PALB2-related disorder |
| RS1555461385 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1555461386 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast |
| RS1555461415 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Breast-ovarian cancer |
| RS1555461551 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555461595 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1555461602 | Health Risk | Pathogenic/Likely pathogenic | Hereditary breast ovarian cancer syndrome, Familial cancer of breast, Hereditary breast ovarian cancer syndrome |
| RS1555461611 | Health Risk | Pathogenic/Likely pathogenic | Hereditary breast ovarian cancer syndrome, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1555461618 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary breast ovarian cancer syndrome, Familial cancer of breast |
| RS1555461634 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1555461870 | Health Risk | Pathogenic/Likely pathogenic | Hereditary breast ovarian cancer syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1555461875 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Breast-ovarian cancer |
| RS1555462026 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Breast-ovarian cancer |
| RS1555462076 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1567206756 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1567206823 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1567209835 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1567213829 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1567214493 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1567217898 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1567221521 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1567221761 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary breast ovarian cancer syndrome, Hereditary cancer-predisposing syndrome |
| RS1597061983 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1597062038 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Malignant tumor of breast |
| RS1597062083 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1597062406 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Familial cancer of breast |
| RS1597079711 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1597088811 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Breast-ovarian cancer, familial |
| RS1597090903 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1597091425 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1597091518 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Malignant tumor of breast, Familial cancer of breast |
| RS1597096243 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Hereditary breast ovarian cancer syndrome, Gastric cancer |
| RS1597096949 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1597097936 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1597098739 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1597098943 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary cancer-predisposing syndrome |
| RS1597098960 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS1597101885 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Familial cancer of breast |
| RS180177083 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Hereditary breast ovarian cancer syndrome |
| RS180177100 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Familial cancer of breast, Hereditary breast ovarian cancer syndrome |
| RS180177112 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS180177122 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Pancreatic cancer |
| RS180177127 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Breast-ovarian cancer |
| RS180177133 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Fanconi anemia complementation group N, Hereditary cancer-predisposing syndrome |
| RS180177142 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group N |
| RS1833331932 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Hereditary cancer-predisposing syndrome, Familial cancer of breast |
| RS1966404530 | Health Risk | Pathogenic/Likely pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1966510953 | Health Risk | Pathogenic/Likely pathogenic | Familial cancer of breast, Familial cancer of breast |