DICER1 Chromosome 14

Dicer 1, ribonuclease III

929 variants 929 Health Risk

Upload your DNA to see your personal genotypes for variants in DICER1.

What This Gene Does

This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2021]

Gene Info

Gene Group

"Endoribonucleases|MicroRNA protein coding host genes|RISC loading complex subunits"

Locus Type

gene with protein product

Location

14q32.13

Ensembl

ENSG00000100697

Associated Conditions (37)

DICER1-related tumor predisposition

Hereditary cancer-predisposing syndrome

Pleuropulmonary blastoma

Euthyroid goiter

Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome

Rhabdomyosarcoma

embryonal

Ovarian cancer

DICER1-related disorder

Breast neoplasm

Primary intracranial sarcoma

DICER1-mutant

Sertoli-Leydig cell tumor

Follicular thyroid carcinoma

Papillary thyroid carcinoma

Cancer or benign tumor

Sarcoma

Pediatric high-grade glioma

Ovarian serous cystadenocarcinoma

+17 more conditions

Key Variants

RS1024226278

Conflicting classifications of pathogenicity

Health Risk

RS1032236740

Conflicting classifications of pathogenicity

Health Risk

RS1045097916

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome

Health Risk

RS1047347414

Conflicting classifications of pathogenicity

Health Risk

RS1060503601

Conflicting classifications of pathogenicity

Health Risk

RS1060503614

Conflicting classifications of pathogenicity

Health Risk

RS1060503616

Conflicting classifications of pathogenicity

Health Risk

RS1060503631

Conflicting classifications of pathogenicity

Health Risk

RS1060503632

Conflicting classifications of pathogenicity

Health Risk

RS1060503647

Conflicting classifications of pathogenicity

Health Risk

RS1060503649

Conflicting classifications of pathogenicity

Health Risk

RS1060503652

Conflicting classifications of pathogenicity

Health Risk

All Variants (929)

RSID	Category	Clinical Significance	Conditions
RS1060503625	Health Risk	Pathogenic	DICER1-related tumor predisposition, Rhabdomyosarcoma, embryonal
RS1060503627	Health Risk	Pathogenic	DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1060503628	Health Risk	Pathogenic	DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1060503633	Health Risk	Pathogenic	DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1060503640	Health Risk	Pathogenic	DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1060503662	Health Risk	Pathogenic	DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1060503665	Health Risk	Pathogenic	DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1064795904	Health Risk	Pathogenic	DICER1-related tumor predisposition, DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1131691189	Health Risk	Pathogenic	Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome
RS1131691190	Health Risk	Pathogenic	Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1131691191	Health Risk	Pathogenic	Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome
RS1131691192	Health Risk	Pathogenic	Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome
RS1131691193	Health Risk	Pathogenic	Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1131691194	Health Risk	Pathogenic	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS1131691196	Health Risk	Pathogenic	Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome
RS1131691197	Health Risk	Pathogenic	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Pleuropulmonary blastoma
RS1131691198	Health Risk	Pathogenic	Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1131691199	Health Risk	Pathogenic	Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome
RS1131691200	Health Risk	Pathogenic	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS1131691201	Health Risk	Pathogenic	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS1131691202	Health Risk	Pathogenic	Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1131691203	Health Risk	Pathogenic	Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1131691206	Health Risk	Pathogenic	Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1131691207	Health Risk	Pathogenic	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS1131691209	Health Risk	Pathogenic	Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1131691210	Health Risk	Pathogenic	Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome
RS1131691212	Health Risk	Pathogenic	Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1131691213	Health Risk	Pathogenic	Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1131691214	Health Risk	Pathogenic	Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1131691215	Health Risk	Pathogenic	Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome
RS1131691216	Health Risk	Pathogenic	Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1131691218	Health Risk	Pathogenic	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS1131691219	Health Risk	Pathogenic	Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1131691220	Health Risk	Pathogenic	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS1131691221	Health Risk	Pathogenic	Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome
RS1131691222	Health Risk	Pathogenic	Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1131691223	Health Risk	Pathogenic	Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1131691224	Health Risk	Pathogenic	Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1131691225	Health Risk	Pathogenic	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS1131691228	Health Risk	Pathogenic	Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome
RS1131691229	Health Risk	Pathogenic	Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1131691231	Health Risk	Pathogenic	Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome
RS1131691232	Health Risk	Pathogenic	Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1170730150	Health Risk	Pathogenic	DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1185406502	Health Risk	Pathogenic	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS1195336111	Health Risk	Pathogenic	DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1263628434	Health Risk	Pathogenic	—
RS1363268262	Health Risk	Pathogenic	Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS137852977	Health Risk	Pathogenic	Pleuropulmonary blastoma, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS137852978	Health Risk	Pathogenic	Pleuropulmonary blastoma, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome

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