DICER1 Chromosome 14

Dicer 1, ribonuclease III
929 variants 929 Health Risk

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What This Gene Does
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2021]
Gene Info
Gene Group
"Endoribonucleases|MicroRNA protein coding host genes|RISC loading complex subunits"
Locus Type
gene with protein product
Location
14q32.13
Ensembl
ENSG00000100697
Associated Conditions (37)
DICER1-related tumor predisposition
Hereditary cancer-predisposing syndrome
Pleuropulmonary blastoma
Euthyroid goiter
Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome
Rhabdomyosarcoma
embryonal
2
Ovarian cancer
DICER1-related disorder
Breast neoplasm
Primary intracranial sarcoma
DICER1-mutant
Sertoli-Leydig cell tumor
Follicular thyroid carcinoma
Papillary thyroid carcinoma
Cancer or benign tumor
Sarcoma
Pediatric high-grade glioma
Ovarian serous cystadenocarcinoma
+17 more conditions
Key Variants
RS1024226278
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1032236740
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Pleuropulmonary blastoma, Euthyroid goiter
Health Risk
RS1045097916
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1047347414
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503601
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503614
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Ovarian cancer
Health Risk
RS1060503616
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503631
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503632
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503647
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503649
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related disorder
Health Risk
RS1060503652
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome
Health Risk
All Variants (929)
RSID Category Clinical Significance Conditions
RS137852979 Health Risk Pathogenic Pleuropulmonary blastoma, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome
RS1397948000 Health Risk Pathogenic DICER1-related tumor predisposition, Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome, Hereditary cancer-predisposing syndrome
RS140875148 Health Risk Pathogenic DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1421729263 Health Risk Pathogenic DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1461043339 Health Risk Pathogenic DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1488644936 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1555366197 Health Risk Pathogenic DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1555366979 Health Risk Pathogenic DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Juvenile type testicular granulosa cell tumor
RS1555367522 Health Risk Pathogenic DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1555367927 Health Risk Pathogenic DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1555369579 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1555370268 Health Risk Pathogenic DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1555370915 Health Risk Pathogenic DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1555371565 Health Risk Pathogenic DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1555371596 Health Risk Pathogenic DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1555371642 Health Risk Pathogenic DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1555372838 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1555372851 Health Risk Pathogenic DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1555373228 Health Risk Pathogenic DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1555374679 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1555374734 Health Risk Pathogenic DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1555374817 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1555374839 Health Risk Pathogenic DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1555375333 Health Risk Pathogenic DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1555375356 Health Risk Pathogenic DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1555375946 Health Risk Pathogenic DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS1555375978 Health Risk Pathogenic DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS1555376174 Health Risk Pathogenic DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1555376368 Health Risk Pathogenic DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1555376375 Health Risk Pathogenic DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS1555376548 Health Risk Pathogenic DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS1566746106 Health Risk Pathogenic DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS1566749829 Health Risk Pathogenic DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1566750865 Health Risk Pathogenic DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS1566767799 Health Risk Pathogenic DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS1566768179 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome
RS1566768212 Health Risk Pathogenic DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1566802002 Health Risk Pathogenic DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1566803555 Health Risk Pathogenic DICER1-related tumor predisposition, Euthyroid goiter, Pleuropulmonary blastoma
RS1595314576 Health Risk Pathogenic Euthyroid goiter, Pleuropulmonary blastoma, DICER1-related tumor predisposition
RS1595315343 Health Risk Pathogenic DICER1-related tumor predisposition, DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1595331224 Health Risk Pathogenic Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome, DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1595331264 Health Risk Pathogenic DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Neoplasm
RS1595340380 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1595341965 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1595363556 Health Risk Pathogenic DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1595364159 Health Risk Pathogenic DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1595364250 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome
RS1595365532 Health Risk Pathogenic DICER1-related tumor predisposition, DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS1595365941 Health Risk Pathogenic Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome
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