DICER1 Chromosome 14
Dicer 1, ribonuclease III
Upload your DNA to see your personal genotypes for variants in DICER1.
What This Gene Does
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2021]
Gene Info
Gene Group
"Endoribonucleases|MicroRNA protein coding host genes|RISC loading complex subunits"
Locus Type
gene with protein product
Location
14q32.13
Ensembl
ENSG00000100697
Associated Conditions (37)
DICER1-related tumor predisposition
Hereditary cancer-predisposing syndrome
Pleuropulmonary blastoma
Euthyroid goiter
Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome
Rhabdomyosarcoma
embryonal
2
Ovarian cancer
DICER1-related disorder
Breast neoplasm
Primary intracranial sarcoma
DICER1-mutant
Sertoli-Leydig cell tumor
Follicular thyroid carcinoma
Papillary thyroid carcinoma
Cancer or benign tumor
Sarcoma
Pediatric high-grade glioma
Ovarian serous cystadenocarcinoma
+17 more conditions
Key Variants
RS1024226278
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1032236740
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Pleuropulmonary blastoma, Euthyroid goiter
Health Risk
RS1045097916
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1047347414
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503601
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503614
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Ovarian cancer
Health Risk
RS1060503616
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503631
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503632
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503647
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503649
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related disorder
Health Risk
RS1060503652
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome
Health Risk
All Variants (929)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1595367266 | Health Risk | Pathogenic | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1595372666 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1595372924 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1595374375 | Health Risk | Pathogenic | Euthyroid goiter, DICER1-related tumor predisposition, Euthyroid goiter |
| RS1595381795 | Health Risk | Pathogenic | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1595396643 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1595410942 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1595411687 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome |
| RS1595414962 | Health Risk | Pathogenic | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1595438051 | Health Risk | Pathogenic | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1595438347 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1595438867 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1595447658 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1595458724 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome |
| RS1595466068 | Health Risk | Pathogenic | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1889794873 | Health Risk | Pathogenic | — |
| RS1889798515 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1889801913 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1889805730 | Health Risk | Pathogenic | DICER1-related tumor predisposition, Ovarian gynandroblastoma, Follicular thyroid carcinoma |
| RS1889806272 | Health Risk | Pathogenic | DICER1-related tumor predisposition, Sertoli-Leydig cell tumor, Papillary thyroid carcinoma |
| RS1889808547 | Health Risk | Pathogenic | DICER1-related tumor predisposition, Follicular thyroid carcinoma, DICER1-related tumor predisposition |
| RS1889809530 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1889810279 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1889814539 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1890067345 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1890068894 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1890079630 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1890097519 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1890098380 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1890098663 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition, Primary intracranial sarcoma |
| RS1890099387 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1890100882 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1890101135 | Health Risk | Pathogenic | DICER1-related tumor predisposition, Primary intracranial sarcoma, DICER1-mutant |
| RS1890101390 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome |
| RS1890260072 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1890264859 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1890265960 | Health Risk | Pathogenic | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1890266885 | Health Risk | Pathogenic | — |
| RS1890320100 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1890322492 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1890324311 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1890334025 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1890349244 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1890350105 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1890372937 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1891064076 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1891066038 | Health Risk | Pathogenic | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1891071442 | Health Risk | Pathogenic | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1891073366 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1891076536 | Health Risk | Pathogenic | DICER1-related tumor predisposition, DICER1-related tumor predisposition |