CYP2C19 Chromosome 10

Cytochrome P450 family 2 subfamily C member 19

30 variants 30 Drug Response

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What This Gene Does

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]

Gene Info

Gene Group

Cytochrome P450 family 2

Locus Type

gene with protein product

Location

10q23.33

Ensembl

ENSG00000165841

Associated Conditions (11)

CYP2C19: uncertain function

CYP2C19: decreased function

CYP2C19: increased function

Clopidogrel response

CYP2C19: no function

warfarin response - Dosage

CYP2C19: normal function

MEPHENYTOIN

POOR METABOLISM OF

Acute coronary syndrome

PROGUANIL

Key Variants

RS118203756

drug response

CYP2C19: uncertain function, CYP2C19: uncertain function

Drug Response

RS118203759

drug response

CYP2C19: decreased function, CYP2C19: decreased function

Drug Response

RS12248560

drug response

CYP2C19: increased function, Clopidogrel response, CYP2C19: increased function

Drug Response

RS12769205

drug response

CYP2C19: no function, CYP2C19: no function

Drug Response

RS12777823

drug response

warfarin response - Dosage, warfarin response - Dosage

Drug Response

RS1288601658

drug response

CYP2C19: uncertain function, CYP2C19: uncertain function

Drug Response

RS138142612

drug response

CYP2C19: normal function, CYP2C19: normal function

Drug Response

RS140278421

drug response

CYP2C19: no function, CYP2C19: no function

Drug Response

RS145328984

drug response

CYP2C19: uncertain function, CYP2C19: uncertain function

Drug Response

RS1564656981

drug response

CYP2C19: uncertain function, CYP2C19: uncertain function

Drug Response

RS1564657013

drug response

CYP2C19: decreased function, CYP2C19: decreased function

Drug Response

RS1564660997

drug response

CYP2C19: uncertain function, CYP2C19: uncertain function

Drug Response

Drug Interactions (5)

Clopidogrel efficacy strong

RS4244285

CYP2C19*2 — poor metaboliser, reduced antiplatelet effect

Clopidogrel efficacy strong

RS12248560

CYP2C19*17 — ultra-rapid metaboliser, enhanced effect

Omeprazole metabolism strong

RS4244285

CYP2C19*2 — poor metaboliser, increased drug levels

Escitalopram metabolism moderate

RS4244285

CYP2C19*2 — may need dose reduction

Sertraline metabolism moderate

RS4244285

CYP2C19*2 — may need dose adjustment

All Variants (30)

RSID	Category	Clinical Significance	Conditions
RS118203756	Drug Response	drug response	CYP2C19: uncertain function, CYP2C19: uncertain function
RS118203759	Drug Response	drug response	CYP2C19: decreased function, CYP2C19: decreased function
RS12248560	Drug Response	drug response	CYP2C19: increased function, Clopidogrel response, CYP2C19: increased function
RS12769205	Drug Response	drug response	CYP2C19: no function, CYP2C19: no function
RS12777823	Drug Response	drug response	warfarin response - Dosage, warfarin response - Dosage
RS1288601658	Drug Response	drug response	CYP2C19: uncertain function, CYP2C19: uncertain function
RS138142612	Drug Response	drug response	CYP2C19: normal function, CYP2C19: normal function
RS140278421	Drug Response	drug response	CYP2C19: no function, CYP2C19: no function
RS145328984	Drug Response	drug response	CYP2C19: uncertain function, CYP2C19: uncertain function
RS1564656981	Drug Response	drug response	CYP2C19: uncertain function, CYP2C19: uncertain function
RS1564657013	Drug Response	drug response	CYP2C19: decreased function, CYP2C19: decreased function
RS1564660997	Drug Response	drug response	CYP2C19: uncertain function, CYP2C19: uncertain function
RS17879685	Drug Response	drug response	CYP2C19: normal function, CYP2C19: normal function
RS17882687	Drug Response	drug response	CYP2C19: normal function, CYP2C19: normal function
RS17884712	Drug Response	drug response	CYP2C19: decreased function, CYP2C19: decreased function
RS192154563	Drug Response	drug response	CYP2C19: decreased function, CYP2C19: decreased function
RS28399504	Drug Response	drug response	MEPHENYTOIN, POOR METABOLISM OF, CYP2C19: no function
RS370803989	Drug Response	drug response	CYP2C19: uncertain function, CYP2C19: uncertain function
RS375781227	Drug Response	drug response	CYP2C19: decreased function, CYP2C19: decreased function
RS41291556	Drug Response	drug response	CYP2C19: no function, CYP2C19: no function
RS4244285	Drug Response	drug response	Acute coronary syndrome, Acute coronary syndrome
RS4986893	Drug Response	drug response	MEPHENYTOIN, POOR METABOLISM OF, PROGUANIL
RS55640102	Drug Response	drug response	CYP2C19: uncertain function, CYP2C19: uncertain function
RS55752064	Drug Response	drug response	CYP2C19: uncertain function, CYP2C19: uncertain function
RS56337013	Drug Response	drug response	MEPHENYTOIN, POOR METABOLISM OF, CYP2C19: no function
RS58973490	Drug Response	drug response	CYP2C19: normal function, CYP2C19: normal function
RS6413438	Drug Response	drug response	CYP2C19: decreased function, CYP2C19: decreased function
RS72552267	Drug Response	drug response	CYP2C19: no function, CYP2C19: no function
RS72558186	Drug Response	drug response	CYP2C19: no function, CYP2C19: no function
RS7902257	Drug Response	drug response	CYP2C19: uncertain function, CYP2C19: uncertain function