RS12777823 CYP2C19

Drug Response Chr 10:94645744 snv intergenic variant

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What This Variant Does

"JAMA rs12777823 and rs4244285 implicated in platelet response to clopidogrel

Associated Conditions

warfarin response - Dosage

GWAS Studies (3)

Trait	Risk Allele	OR / Beta	P-value	Study
Response to clopidogrel therapy	—	—	2E-13	PubMed
Warfarin maintenance dose	—	—	5E-12	PubMed
Warfarin maintenance dose (adjusted for clinical factors)	A	OR: 0.13	3E-11	PubMed

Population Frequencies

1kG AFR

25.1%

1kG ALL

75.5%

1kG AMR

10.7%

1kG EAS

31.4%

1kG EUR

15.1%

1kG SAS

36.2%

Other Variants in CYP2C19