RS3892097 CYP2D6

Drug Response Chr 22:42128944 snv splice acceptor variant
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What This Variant Does
"The normal (or wild type) form of this SNP is a (G). The (A) form disrupts proper mRNA formation, re...
Associated Conditions
Debrisoquine
poor metabolism of
Tamoxifen response
Tramadol response
Deutetrabenazine response
Familial cancer of breast
Uveal melanoma
Malignant lymphoma
large B-cell
diffuse
Melanoma
Uterine carcinosarcoma
Acute myeloid leukemia
Debrisoquine
poor metabolism of
Medication Interactions
Codeine metabolism strong
CYP2D6*4 — poor metaboliser, reduced codeine-to-morphine conversion
Tramadol metabolism strong
CYP2D6*4 — reduced efficacy of tramadol
Tamoxifen efficacy strong
CYP2D6*4 — reduced conversion to active metabolite endoxifen
Fluoxetine metabolism moderate
CYP2D6*4 — may need dose adjustment
Paroxetine metabolism moderate
CYP2D6*4 — substrate of CYP2D6
GWAS Studies (3)
Trait Risk Allele OR / Beta P-value Study
Plasma solanidine levels in chronic kidney disease T OR: 0.82 5E-51 PubMed
Urinary metabolite levels in chronic kidney disease T OR: 1.7 6E-16 PubMed
Urine alpha-hydroxymetoprolol levels in chronic kidney disease T OR: 1.67 1E-15 PubMed
Population Frequencies
gnomAD ALL
100%
1kG AFR
93.9%
1kG ALL
90.7%
1kG AMR
13%
1kG EAS
0.2%
1kG EUR
18.6%
1kG SAS
10.9%
Other Variants in CYP2D6
rs5030655 rs1065852 rs28371725 rs267608275 rs730882251 rs267608319 rs373000587 rs730882170 rs1602563541 rs1252450087
Ask Dr. Hemsworth about this variant