RS268 LPL
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What This Variant Does
"rs268, also known as LPL '''Asn291Ser''' as well as '''LPL N291S''' or '''N318S''', a SNP in the lip...
Associated Conditions
Hyperlipidemia
familial combined
LPL related
susceptibility to
Hyperlipoproteinemia
type I
Cardiovascular phenotype
Hyperlipidemia
familial combined
LPL related
susceptibility to
Hyperlipoproteinemia
type I
Cardiovascular phenotype
GWAS Studies (20)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Haematocrit percentage (UKB data field 30030) | G | OR: 0.22 | 4E-272 | PubMed |
| High density lipoprotein cholesterol levels | G | OR: 0.3 | 7E-220 | PubMed |
| Triglyceride levels (UKB data field 30870) | G | OR: 0.21 | 2E-197 | PubMed |
| Apolipoprotein A levels (UKB data field 30630) | G | OR: 0.19 | 6E-184 | PubMed |
| Triglyceride levels | G | OR: 0.25 | 6E-166 | PubMed |
| Triglyceride levels (MTAG) | A | OR: 0.24 | 2E-146 | PubMed |
| Apolipoprotein A1 levels | G | OR: 0.24 | 6E-145 | PubMed |
| High-density lipoprotein levels (MTAG) | A | OR: 0.24 | 7E-137 | PubMed |
| Triglyceride to HDL cholesterol ratio | G | OR: 0.29 | 1E-136 | PubMed |
| Monounsaturated fatty acids to total fatty acids percentage | G | — | 5E-103 | PubMed |
| Triglyceride to HDL cholesterol ratio | G | OR: 0.29 | 2E-100 | PubMed |
| Monounsaturated fatty acids to total fatty acids percentage | G | — | 3E-99 | PubMed |
| Triglyceride to HDL cholesterol ratio | G | OR: 0.28 | 1E-87 | PubMed |
| Polyunsaturated fatty acids to monounsaturated fatty acids ratio | G | — | 3E-79 | PubMed |
| Polyunsaturated fatty acids to monounsaturated fatty acids ratio | G | — | 9E-78 | PubMed |
| Cholesteryl Esters in Large VLDL | G | OR: 0.2 | 3E-77 | PubMed |
| Cholesteryl esters in very large VLDL | G | OR: 0.19 | 5E-75 | PubMed |
| Metabolic dysfunction-associated steatotic liver disease (MTAG) | A | OR: 0.25 | 9E-65 | PubMed |
| Phospholipids to Total Lipids in Very Large HDL percentage | G | OR: 0.16 | 2E-59 | PubMed |
| Monounsaturated fatty acids to total fatty acids percentage | G | — | 5E-57 | PubMed |
Other Variants in LPL