RS138326449 APOC3
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What This Variant Does
"rs138326449, also known as IVS2 1G>
Associated Conditions
Coronary heart disease
Apolipoprotein c-III deficiency
Cardiovascular phenotype
Clear cell carcinoma of kidney
Coronary heart disease
Apolipoprotein c-III deficiency
Cardiovascular phenotype
Clear cell carcinoma of kidney
GWAS Studies (20)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Triglyceride levels | — | OR: 1.26 | 2E-787 | PubMed |
| HDL cholesterol levels | — | OR: 0.99 | 1E-500 | PubMed |
| Apolipoprotein A1 levels | — | OR: 0.84 | 1E-325 | PubMed |
| HDL cholesterol | A | OR: 0.73 | 5E-134 | PubMed |
| Monounsaturated fatty acids to total fatty acids percentage | A | — | 4E-103 | PubMed |
| Monounsaturated fatty acids to total fatty acids percentage | A | — | 6E-97 | PubMed |
| Polyunsaturated fatty acids to monounsaturated fatty acids ratio | A | — | 2E-88 | PubMed |
| Polyunsaturated fatty acids to monounsaturated fatty acids ratio | A | — | 2E-83 | PubMed |
| Omega-6 fatty acids to total fatty acids percentage | A | — | 2E-74 | PubMed |
| Omega-6 fatty acids to total fatty acids percentage | A | — | 4E-66 | PubMed |
| Monounsaturated fatty acids to total fatty acids percentage | A | — | 6E-63 | PubMed |
| Monounsaturated fatty acid levels | A | — | 2E-59 | PubMed |
| Monounsaturated fatty acids to total fatty acids percentage | A | — | 3E-58 | PubMed |
| Polyunsaturated fatty acids to monounsaturated fatty acids ratio | A | — | 1E-55 | PubMed |
| Monounsaturated fatty acid levels | A | — | 2E-55 | PubMed |
| Polyunsaturated fatty acids to total fatty acids percentage | A | — | 2E-53 | PubMed |
| Polyunsaturated fatty acids to monounsaturated fatty acids ratio | A | — | 1E-51 | PubMed |
| Polyunsaturated fatty acids to total fatty acids percentage | A | — | 2E-49 | PubMed |
| Red cell distribution width | — | OR: 0.32 | 8E-49 | PubMed |
| Omega-6 fatty acids to total fatty acids percentage | A | — | 1E-47 | PubMed |
ClinVar Assertions (2)
NM_000040.3(APOC3):c.55+1G>A
NM_000040.3(APOC3):c.55+1G>A
Population Frequencies
gnomAD ALL
99.8%
1kG AFR
100%
1kG ALL
99.9%
1kG AMR
100%
1kG EAS
0.1%
1kG EUR
99.7%
1kG SAS
100%
Other Variants in APOC3