RS12913832 HERC2
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What This Variant Does
"rs12913832 is a SNP near the OCA2 gene that may be functionally linked to blue or brown eye color, d...
Associated Conditions
SKIN/HAIR/EYE PIGMENTATION 1
BLUE/NONBLUE EYES
SKIN/HAIR/EYE PIGMENTATION 1
BLUE/NONBLUE EYES
GWAS Studies (20)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Cutaneous melanoma or hair colour | A | — | 2E-9237 | PubMed |
| Brown vs. black hair color | — | OR: 2.23 | 2E-308 | PubMed |
| Blond vs. brown/black hair color | — | OR: 4.69 | 2E-308 | PubMed |
| Eye color traits | — | — | 1E-300 | PubMed |
| Eye color | — | — | 1E-200 | PubMed |
| Skin, hair and eye pigmentation (multivariate analysis) | — | — | 1E-200 | PubMed |
| Eye color (brightness) | — | — | 1E-200 | PubMed |
| Low tan response | A | OR: 0.31 | 6E-184 | PubMed |
| Hair color | G | OR: 0.39 | 1E-167 | PubMed |
| Eye color | G | OR: 2.84 | 1E-158 | PubMed |
| Skin phototype score | G | OR: 6.88 | 5E-147 | PubMed |
| Blond vs. brown/black hair color | A | OR: 1.19 | 5E-141 | PubMed |
| Skin color (Fitzpatrick scale) | G | OR: 0.33 | 6E-126 | PubMed |
| Actinic keratosis (PheCode 702.1) | A | OR: 0.13 | 3E-107 | PubMed |
| Hair color | — | — | 8E-105 | PubMed |
| Hair color | — | — | 5E-104 | PubMed |
| Black vs. blond hair color | A | OR: 0.44 | 4E-103 | PubMed |
| Hair morphology traits | — | OR: 0.35 | 2E-101 | PubMed |
| Hair color | A | OR: 0.5 | 1E-100 | PubMed |
| Eye color (hue) | — | — | 1E-92 | PubMed |
Other Variants in HERC2