RS1667394 HERC2

Health Risk Chr 15:28285035 snv intron variant

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What This Variant Does

"rs1667394 increases susceptibility to Blond rather than brown hair 4.94 times for carriers of the A ...

Associated Conditions

SKIN/HAIR/EYE PIGMENTATION 1

BLUE/NONBLUE EYES

SKIN/HAIR/EYE PIGMENTATION 1

BLUE/NONBLUE EYES

GWAS Studies (9)

Trait	Risk Allele	OR / Beta	P-value	Study
Blue vs. brown eyes	A	OR: 29.43	1E-241	PubMed
Eye color traits	—	OR: 1.84	5E-163	PubMed
Low tan response	C	OR: 0.23	4E-78	PubMed
Blond vs. brown/black hair color	C	OR: 1.01	3E-77	PubMed
Blue vs. green eyes	A	OR: 6.74	2E-53	PubMed
Blond vs. brown hair color	A	OR: 4.94	6E-35	PubMed
Brown vs. black hair color	C	OR: 0.63	4E-22	PubMed
Eye color	C	OR: 0.35	2E-20	PubMed
Adiponectin levels	T	OR: 0.13	2E-6	PubMed

Population Frequencies

1kG AFR

8.7%

1kG ALL

62%

1kG AMR

56.5%

1kG EAS

27.1%

1kG EUR

24.4%

1kG SAS

63.2%

Other Variants in HERC2