RS12654264 HMGCR
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What This Variant Does
"Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity ...
Associated Conditions
Low density lipoprotein cholesterol level quantitative trait locus 3
Low density lipoprotein cholesterol level quantitative trait locus 3
GWAS Studies (10)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| LDL cholesterol | T | β: 0.1 | 1E-20 | PubMed |
| Metabolite levels | T | OR: 2.71 | 1E-20 | PubMed |
| Total cholesterol levels | — | OR: 3.23 | 7E-20 | PubMed |
| Triglycerides in small LDL | A | β: 0.036 | 2E-19 | PubMed |
| Low density lipoprotein cholesterol levels | — | OR: 2.82 | 7E-19 | PubMed |
| Triglycerides in medium LDL | A | β: 0.035 | 1E-18 | PubMed |
| Cholesterol esters in very large VLDL | A | β: 0.027 | 5E-11 | PubMed |
| Cholesterol | T | OR: 2.63 | 1E-9 | PubMed |
| Total cholesterol levels | T | β: 0.06 | 3E-7 | PubMed |
| Low density lipoprotein cholesterol levels | — | — | 1E-6 | PubMed |
Other Variants in HMGCR