RS12916 HMGCR

Drug Response Chr 5:75360713 snv 3 prime UTR variant

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What This Variant Does

"http://www.medscape.com/viewarticle/832327 Each additional allele of rs17238484(G) was associated wi..."

Associated Conditions

Statins

attenuated cholesterol lowering by

Statins

attenuated cholesterol lowering by

GWAS Studies (20)

Trait	Risk Allele	OR / Beta	P-value	Study
Low density lipoprotein cholesterol levels	—	—	1E-602	PubMed
Total cholesterol levels	—	—	2E-546	PubMed
Low density lipoprotein cholesterol levels	C	β: 0.07	2E-401	PubMed
Non-HDL cholesterol levels	—	—	2E-399	PubMed
Total cholesterol levels	C	β: 0.066	2E-351	PubMed
Non-HDL cholesterol levels	C	β: 0.068	3E-261	PubMed
Low density lipoprotein cholesterol levels	—	β: 0.083	1E-222	PubMed
LDL cholesterol levels	T	β: 0.062	2E-187	PubMed
Direct low density lipoprotein levels (UKB data field 30780)	C	β: 0.059	5E-176	PubMed
LDL cholesterol	C	β: 0.06	5E-173	PubMed
Total cholesterol levels	C	β: 0.054	6E-168	PubMed
Cholesterol levels (UKB data field 30690)	C	β: 0.056	9E-165	PubMed
low density lipoprotein cholesterol (LDLC, maximum, inv-norm transformed)	T	β: 0.069	2E-164	PubMed
low density lipoprotein cholesterol (LDLC, mean, inv-norm transformed)	T	β: 0.069	2E-160	PubMed
total cholesterol (mean, inv-norm transformed)	T	β: 0.068	8E-155	PubMed
total cholesterol (maximum, inv-norm transformed)	T	β: 0.067	6E-150	PubMed
Apolipoprotein B levels	T	β: 0.055	9E-148	PubMed
low density lipoprotein cholesterol (LDLC, maximum, inv-norm transformed)	T	β: 0.065	7E-147	PubMed
low density lipoprotein cholesterol (LDLC, mean, inv-norm transformed)	T	β: 0.063	2E-134	PubMed
total cholesterol (maximum, inv-norm transformed)	T	β: 0.062	9E-132	PubMed

Population Frequencies

gnomAD ALL

58.7%

1kG AFR

23.4%

1kG ALL

58.4%

1kG AMR

42.9%

1kG EAS

48.9%

1kG EUR

58.7%

1kG SAS

55.8%

Other Variants in HMGCR