SUOX Chromosome 12

Sulfite oxidase
91 variants 91 Health Risk

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What This Gene Does
Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit contains a heme domain and a molybdopterin-binding domain. The enzyme catalyzes the oxidation of sulfite to sulfate, the final reaction in the oxidative degradation of the sulfur amino acids cysteine and methionine. Sulfite oxidase deficiency results in neurological abnormalities which are often fatal at an early age. Alternative splicing results in multiple transcript variants encoding identical proteins. [provided by RefSeq, Jul 2008]
Associated Conditions (13)
Sulfite oxidase deficiency
Inborn genetic diseases
SUOX-related disorder
Clear cell carcinoma of kidney
Gastric cancer
Ovarian serous cystadenocarcinoma
Thyroid cancer
nonmedullary
1
Uterine carcinosarcoma
Malignant tumor of urinary bladder
Nonpapillary renal cell carcinoma
Sulfocysteinuria
Key Variants
RS139444405
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency, Inborn genetic diseases, Sulfite oxidase deficiency
Health Risk
RS141432255
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency, Sulfite oxidase deficiency
Health Risk
RS143457531
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency, Sulfite oxidase deficiency
Health Risk
RS144064367
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency, Sulfite oxidase deficiency
Health Risk
RS146626318
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency, Inborn genetic diseases, Sulfite oxidase deficiency
Health Risk
RS1565799921
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency, Sulfite oxidase deficiency
Health Risk
RS1592831898
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency, Sulfite oxidase deficiency
Health Risk
RS202085145
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency, SUOX-related disorder, Inborn genetic diseases
Health Risk
RS2540574448
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency, Sulfite oxidase deficiency
Health Risk
RS368327991
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency, Sulfite oxidase deficiency
Health Risk
RS375363943
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency, Inborn genetic diseases, Sulfite oxidase deficiency
Health Risk
RS540792428
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency, Sulfite oxidase deficiency
Health Risk
All Variants (91)
RSID Category Clinical Significance Conditions
RS139444405 Health Risk Conflicting classifications of pathogenicity Sulfite oxidase deficiency, Inborn genetic diseases, Sulfite oxidase deficiency
RS141432255 Health Risk Conflicting classifications of pathogenicity Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS143457531 Health Risk Conflicting classifications of pathogenicity Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS144064367 Health Risk Conflicting classifications of pathogenicity Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS146626318 Health Risk Conflicting classifications of pathogenicity Sulfite oxidase deficiency, Inborn genetic diseases, Sulfite oxidase deficiency
RS1565799921 Health Risk Conflicting classifications of pathogenicity Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS1592831898 Health Risk Conflicting classifications of pathogenicity Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS202085145 Health Risk Conflicting classifications of pathogenicity Sulfite oxidase deficiency, SUOX-related disorder, Inborn genetic diseases
RS2540574448 Health Risk Conflicting classifications of pathogenicity Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS368327991 Health Risk Conflicting classifications of pathogenicity Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS375363943 Health Risk Conflicting classifications of pathogenicity Sulfite oxidase deficiency, Inborn genetic diseases, Sulfite oxidase deficiency
RS540792428 Health Risk Conflicting classifications of pathogenicity Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS574353697 Health Risk Conflicting classifications of pathogenicity Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS577360771 Health Risk Conflicting classifications of pathogenicity Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS759255030 Health Risk Conflicting classifications of pathogenicity Sulfite oxidase deficiency, Sulfocysteinuria, Sulfite oxidase deficiency
RS759992645 Health Risk Conflicting classifications of pathogenicity Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS760901724 Health Risk Conflicting classifications of pathogenicity Sulfite oxidase deficiency, Sulfocysteinuria, Inborn genetic diseases
RS763253683 Health Risk Conflicting classifications of pathogenicity Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS765012855 Health Risk Conflicting classifications of pathogenicity Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS765738385 Health Risk Conflicting classifications of pathogenicity Inborn genetic diseases, Sulfite oxidase deficiency, Inborn genetic diseases
RS765859233 Health Risk Conflicting classifications of pathogenicity Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS770389350 Health Risk Conflicting classifications of pathogenicity Inborn genetic diseases, Sulfite oxidase deficiency, SUOX-related disorder
RS781081194 Health Risk Conflicting classifications of pathogenicity Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS121908009 Health Risk Likely pathogenic Sulfite oxidase deficiency, Sulfocysteinuria, Sulfite oxidase deficiency
RS1273768268 Health Risk Likely pathogenic Sulfocysteinuria, Sulfite oxidase deficiency, Sulfocysteinuria
RS1435587153 Health Risk Likely pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS1478487771 Health Risk Likely pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS1565798380 Health Risk Likely pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS1890630965 Health Risk Likely pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS1890647333 Health Risk Likely pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS2136513466 Health Risk Likely pathogenic —
RS370951378 Health Risk Likely pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS766949012 Health Risk Likely pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS770792767 Health Risk Likely pathogenic Sulfite oxidase deficiency, Sulfocysteinuria, Sulfite oxidase deficiency
RS777114729 Health Risk Likely pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS778431071 Health Risk Likely pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS781351306 Health Risk Likely pathogenic Sulfocysteinuria, Sulfocysteinuria
RS794729211 Health Risk Likely pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS1171191979 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS1175117475 Health Risk Pathogenic Sulfite oxidase deficiency, SUOX-related disorder, Sulfite oxidase deficiency
RS1370270518 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS1372045486 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS1389312412 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS144469629 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS1446408066 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS1451449404 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS1460210127 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS1555198521 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS1565798201 Health Risk Pathogenic Inborn genetic diseases, Sulfite oxidase deficiency, Inborn genetic diseases
RS1592829198 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
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