SUOX Chromosome 12

Sulfite oxidase
91 variants 91 Health Risk

Upload your DNA to see your personal genotypes for variants in SUOX.

What This Gene Does
Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit contains a heme domain and a molybdopterin-binding domain. The enzyme catalyzes the oxidation of sulfite to sulfate, the final reaction in the oxidative degradation of the sulfur amino acids cysteine and methionine. Sulfite oxidase deficiency results in neurological abnormalities which are often fatal at an early age. Alternative splicing results in multiple transcript variants encoding identical proteins. [provided by RefSeq, Jul 2008]
Associated Conditions (13)
Sulfite oxidase deficiency
Inborn genetic diseases
SUOX-related disorder
Clear cell carcinoma of kidney
Gastric cancer
Ovarian serous cystadenocarcinoma
Thyroid cancer
nonmedullary
1
Uterine carcinosarcoma
Malignant tumor of urinary bladder
Nonpapillary renal cell carcinoma
Sulfocysteinuria
Key Variants
RS139444405
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency, Inborn genetic diseases, Sulfite oxidase deficiency
Health Risk
RS141432255
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency, Sulfite oxidase deficiency
Health Risk
RS143457531
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency, Sulfite oxidase deficiency
Health Risk
RS144064367
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency, Sulfite oxidase deficiency
Health Risk
RS146626318
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency, Inborn genetic diseases, Sulfite oxidase deficiency
Health Risk
RS1565799921
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency, Sulfite oxidase deficiency
Health Risk
RS1592831898
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency, Sulfite oxidase deficiency
Health Risk
RS202085145
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency, SUOX-related disorder, Inborn genetic diseases
Health Risk
RS2540574448
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency, Sulfite oxidase deficiency
Health Risk
RS368327991
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency, Sulfite oxidase deficiency
Health Risk
RS375363943
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency, Inborn genetic diseases, Sulfite oxidase deficiency
Health Risk
RS540792428
Conflicting classifications of pathogenicity
Sulfite oxidase deficiency, Sulfite oxidase deficiency
Health Risk
All Variants (91)
RSID Category Clinical Significance Conditions
RS1890558787 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS1890579284 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS1890661164 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS1890663087 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS1890663871 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS1890688726 Health Risk Pathogenic Sulfite oxidase deficiency, SUOX-related disorder, Sulfite oxidase deficiency
RS2136509616 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS2136509843 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS2136512310 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS2136513040 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS2136513148 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS2136513432 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS2540573705 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS2540574261 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS2540575551 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS2540575913 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS2540575955 Health Risk Pathogenic Sulfite oxidase deficiency, SUOX-related disorder, Sulfite oxidase deficiency
RS2540575967 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS2540576131 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS2540576238 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS2540577060 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS2540577678 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS2540577777 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS2540577829 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS2540577903 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS2540578061 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS2540578127 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS747461754 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS757559168 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfocysteinuria, Sulfite oxidase deficiency
RS773655286 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS773937413 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS780603746 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfocysteinuria, SUOX-related disorder
RS867210538 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS988221869 Health Risk Pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS121908007 Health Risk Pathogenic/Likely pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS1314125524 Health Risk Pathogenic/Likely pathogenic SUOX-related disorder, Sulfite oxidase deficiency, SUOX-related disorder
RS748900391 Health Risk Pathogenic/Likely pathogenic Inborn genetic diseases, SUOX-related disorder, Sulfocysteinuria
RS758923989 Health Risk Pathogenic/Likely pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS770496917 Health Risk Pathogenic/Likely pathogenic Sulfite oxidase deficiency, Sulfite oxidase deficiency
RS776356158 Health Risk Pathogenic/Likely pathogenic Sulfite oxidase deficiency, Sulfocysteinuria, Sulfite oxidase deficiency
RS776690106 Health Risk Pathogenic/Likely pathogenic Sulfite oxidase deficiency, Sulfocysteinuria, Sulfite oxidase deficiency
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