PNPLA3 Chromosome 22
Patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase
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What This Gene Does
The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"Lipases|Patatin like phospholipase domain containing"
Locus Type
gene with protein product
Location
22q13.31
Ensembl
ENSG00000100344
Associated Conditions (2)
NAFLD1
Hepatic steatosis
Key Variants
Related Biomarkers (2)
ALT (SGPT)
risk if abnormal
strong
GGT
monitor
moderate
Related Supplements (2)
Omega-3 (EPA/DHA) may support
moderate
PNPLA3 — omega-3 may reduce liver fat
Milk Thistle (Silymarin) may support
exploratory
PNPLA3 — hepatoprotective properties
All Variants (2)