DICER1 Chromosome 14
Dicer 1, ribonuclease III
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What This Gene Does
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2021]
Gene Info
Gene Group
"Endoribonucleases|MicroRNA protein coding host genes|RISC loading complex subunits"
Locus Type
gene with protein product
Location
14q32.13
Ensembl
ENSG00000100697
Associated Conditions (37)
DICER1-related tumor predisposition
Hereditary cancer-predisposing syndrome
Pleuropulmonary blastoma
Euthyroid goiter
Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome
Rhabdomyosarcoma
embryonal
2
Ovarian cancer
DICER1-related disorder
Breast neoplasm
Primary intracranial sarcoma
DICER1-mutant
Sertoli-Leydig cell tumor
Follicular thyroid carcinoma
Papillary thyroid carcinoma
Cancer or benign tumor
Sarcoma
Pediatric high-grade glioma
Ovarian serous cystadenocarcinoma
+17 more conditions
Key Variants
RS1024226278
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1032236740
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Pleuropulmonary blastoma, Euthyroid goiter
Health Risk
RS1045097916
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1047347414
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503601
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503614
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Ovarian cancer
Health Risk
RS1060503616
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503631
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503632
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503647
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503649
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related disorder
Health Risk
RS1060503652
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome
Health Risk
All Variants (929)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1595381016 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1595407375 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1595438165 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1595440577 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1595447611 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome |
| RS1595448161 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1595448248 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome |
| RS1595457134 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1595459155 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Ovarian cancer, Hereditary cancer-predisposing syndrome |
| RS1595465990 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome |
| RS1595468557 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome |
| RS180918578 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS181018393 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related disorder |
| RS188327838 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related disorder |
| RS1889806807 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Primary intracranial sarcoma, DICER1-mutant |
| RS1889954831 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Rhabdomyosarcoma, embryonal |
| RS1890292272 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1890302137 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome |
| RS1890354220 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1890362623 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1891095978 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1891099996 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS189119295 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1891592805 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1891606034 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome |
| RS1892381031 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1892389194 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1892481172 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1893203328 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1893833599 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1894132373 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS189738689 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS191567701 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related disorder |
| RS192822778 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome |
| RS200212137 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related disorder |
| RS200408568 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related disorder |
| RS200890670 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related disorder |
| RS201212908 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Euthyroid goiter |
| RS201298288 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS201358110 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS201842071 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related disorder |
| RS2139780112 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS2139813236 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS2139985624 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS2140030983 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS2140034098 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS2140201750 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS2140267838 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS2140279368 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS2140289208 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |