DICER1 Chromosome 14
Dicer 1, ribonuclease III
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What This Gene Does
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2021]
Gene Info
Gene Group
"Endoribonucleases|MicroRNA protein coding host genes|RISC loading complex subunits"
Locus Type
gene with protein product
Location
14q32.13
Ensembl
ENSG00000100697
Associated Conditions (37)
DICER1-related tumor predisposition
Hereditary cancer-predisposing syndrome
Pleuropulmonary blastoma
Euthyroid goiter
Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome
Rhabdomyosarcoma
embryonal
2
Ovarian cancer
DICER1-related disorder
Breast neoplasm
Primary intracranial sarcoma
DICER1-mutant
Sertoli-Leydig cell tumor
Follicular thyroid carcinoma
Papillary thyroid carcinoma
Cancer or benign tumor
Sarcoma
Pediatric high-grade glioma
Ovarian serous cystadenocarcinoma
+17 more conditions
Key Variants
RS1024226278
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1032236740
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Pleuropulmonary blastoma, Euthyroid goiter
Health Risk
RS1045097916
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome
Health Risk
RS1047347414
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503601
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503614
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Ovarian cancer
Health Risk
RS1060503616
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503631
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503632
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503647
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
Health Risk
RS1060503649
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related disorder
Health Risk
RS1060503652
Conflicting classifications of pathogenicity
DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome
Health Risk
All Variants (929)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1422876107 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome |
| RS143533680 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome |
| RS143841809 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome |
| RS144095207 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related disorder |
| RS1447821588 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS145669719 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS145693584 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related disorder |
| RS1464874776 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Ovarian cancer |
| RS1465088683 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, DICER1-related disorder |
| RS146584765 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome |
| RS1479149167 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1481644631 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1486214757 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1488681878 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS148955573 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, DICER1-related disorder |
| RS149718671 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Pleuropulmonary blastoma |
| RS149723645 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related disorder |
| RS151197809 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome |
| RS1555367601 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1555367924 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome |
| RS1555368535 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1555369473 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1555370248 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1555370297 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome |
| RS1555370776 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1555372566 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1555372847 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Ovarian cancer, DICER1-related tumor predisposition |
| RS1555374767 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1555375852 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1555376587 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1566767339 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1566768449 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1566768694 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1566769439 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1566776633 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Ovarian cancer |
| RS1566811476 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1566815070 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome |
| RS1595312698 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1595341062 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome |
| RS1595343204 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome |
| RS1595354040 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1595364529 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome |
| RS1595371059 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, DICER1-related tumor predisposition |
| RS1595374387 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome |
| RS1595379041 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1595379089 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1595379319 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome |
| RS1595379355 | Health Risk | Conflicting classifications of pathogenicity | DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition |
| RS1595380153 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome |
| RS1595381000 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome |