ADRB1 Chromosome 10
Adrenoceptor beta 1
Upload your DNA to see your personal genotypes for variants in ADRB1.
What This Gene Does
The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Beta-1 adrenoceptors are predominately located in the heart. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Sep 2019]
Gene Info
Gene Group
Adrenoceptors
Locus Type
gene with protein product
Location
10q25.3
Ensembl
ENSG00000043591
Associated Conditions (7)
Pulmonary disease
chronic obstructive
susceptibility to
ADRB1-related disorder
SHORT SLEEP
FAMILIAL NATURAL
2
Key Variants
All Variants (2)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1801253 | Health Risk | Benign; association | Pulmonary disease, chronic obstructive, susceptibility to |
| RS776439595 | Health Risk | Pathogenic | SHORT SLEEP, FAMILIAL NATURAL, 2 |