| RS121913147 |
INSR
|
Health Risk |
Conflicting classifications of pathogenicity |
Insulin-resistant diabetes mellitus AND acanthosis nigricans, Rabson-Mendenhall syndrome |
| RS121913148 |
INSR
|
Health Risk |
Likely pathogenic |
Insulin-resistant diabetes mellitus AND acanthosis nigricans, Hyperinsulinism due to INSR deficiency |
| RS121913150 |
INSR
|
Health Risk |
Pathogenic |
Type 2 diabetes mellitus, Type 2 diabetes mellitus |
| RS121913151 |
INSR
|
Health Risk |
Likely pathogenic |
Leprechaunism syndrome, Leprechaunism syndrome |
| RS121913152 |
INSR
|
Health Risk |
Pathogenic |
Leprechaunism syndrome, Leprechaunism syndrome |
| RS121913153 |
INSR
|
Health Risk |
Pathogenic |
Leprechaunism syndrome, Leprechaunism syndrome |
| RS121913154 |
INSR
|
Health Risk |
Pathogenic |
Insulin-resistant diabetes mellitus AND acanthosis nigricans, Insulin-resistant diabetes mellitus AND acanthosis nigricans |
| RS121913155 |
INSR
|
Health Risk |
Pathogenic |
Leprechaunism syndrome, Leprechaunism syndrome |
| RS121913156 |
INSR
|
Health Risk |
Pathogenic |
Insulin-resistant diabetes mellitus AND acanthosis nigricans, Hyperinsulinism due to INSR deficiency |
| RS121913158 |
INSR
|
Health Risk |
Pathogenic |
Leprechaunism syndrome, Leprechaunism syndrome |
| RS121913159 |
INSR
|
Health Risk |
Pathogenic |
Leprechaunism syndrome, Leprechaunism syndrome |
| RS121913160 |
INSR
|
Health Risk |
Pathogenic |
Leprechaunism syndrome, Leprechaunism syndrome |
| RS121913161 |
IL1RN
|
Health Risk |
Pathogenic |
Sterile multifocal osteomyelitis with periostitis and pustulosis, Sterile multifocal osteomyelitis with periostitis and pustulosis |
| RS121913162 |
IL1RN
|
Health Risk |
Pathogenic |
Sterile multifocal osteomyelitis with periostitis and pustulosis, Sterile multifocal osteomyelitis with periostitis and pustulosis |
| RS121913209 |
IFNGR2
|
Health Risk |
Conflicting classifications of pathogenicity |
Immunodeficiency 28, Immunodeficiency 28 |
| RS121913212 |
IFNGR2
|
Health Risk |
Conflicting classifications of pathogenicity |
Immunodeficiency 28, IFNGR2-related disorder |
| RS121913217 |
IFNGR2
|
Health Risk |
Conflicting classifications of pathogenicity |
Immunodeficiency 28, Immunodeficiency 28 |
| RS121913223 |
DHFR
|
Health Risk |
Pathogenic |
Constitutional megaloblastic anemia with severe neurologic disease, Constitutional megaloblastic anemia with severe neurologic disease |
| RS121913224 |
APC
|
Health Risk |
Pathogenic |
Familial adenomatous polyposis 1, ADENOMATOUS POLYPOSIS COLI WITH CONGENITAL CHOLESTEATOMA |
| RS121913233 |
HRAS
|
Health Risk |
Likely pathogenic |
Linear nevus sebaceous syndrome, Vascular Tumors Including Pyogenic Granuloma |
| RS121913234 |
KIT
|
Health Risk |
Pathogenic |
Gastrointestinal stromal tumor, Gastrointestinal stromal tumor |
| RS121913235 |
KIT
|
Health Risk |
Pathogenic/Likely pathogenic |
Gastrointestinal stromal tumor, Hereditary cancer-predisposing syndrome |
| RS121913236 |
KRAS
|
Health Risk |
Pathogenic/Likely pathogenic |
RASopathy, Linear nevus sebaceous syndrome |
| RS121913237 |
NRAS
|
Health Risk |
Pathogenic/Likely pathogenic |
Epidermal nevus, Juvenile myelomonocytic leukemia |
| RS121913238 |
KRAS
|
Health Risk |
Pathogenic |
Non-small cell lung carcinoma, Colon adenocarcinoma |
| RS121913240 |
KRAS
|
Health Risk |
Pathogenic |
Noonan syndrome, RASopathy |
| RS121913243 |
MET
|
Health Risk |
Pathogenic/Likely pathogenic |
Papillary renal cell carcinoma type 1, Renal cell carcinoma |
| RS121913245 |
MET
|
Health Risk |
Likely pathogenic |
Hereditary cancer-predisposing syndrome, Embryonal rhabdomyosarcoma |
| RS121913246 |
MET
|
Health Risk |
Conflicting classifications of pathogenicity |
Papillary renal cell carcinoma type 1, Renal cell carcinoma |
| RS121913250 |
NRAS
|
Health Risk |
Pathogenic |
Chronic myelogenous leukemia, BCR-ABL1 positive |
| RS121913254 |
NRAS
|
Health Risk |
Conflicting classifications of pathogenicity |
Large congenital melanocytic nevus, Neurocutaneous melanocytosis |
| RS121913255 |
NRAS
|
Health Risk |
Conflicting classifications of pathogenicity |
Noonan syndrome and Noonan-related syndrome, Neoplasm |
| RS121913272 |
PIK3CA
|
Health Risk |
Pathogenic |
CLOVES syndrome, Ovarian neoplasm |
| RS121913273 |
PIK3CA
|
Health Risk |
Pathogenic |
CLOVES syndrome, Ovarian neoplasm |
| RS121913274 |
PIK3CA
|
Health Risk |
Pathogenic |
Epidermal nevus, Carcinoma of colon |
| RS121913275 |
PIK3CA
|
Health Risk |
Pathogenic |
PIK3CA related overgrowth syndrome, Megalencephaly-capillary malformation-polymicrogyria syndrome |
| RS121913277 |
PIK3CA
|
Health Risk |
Likely pathogenic |
Megalencephaly-capillary malformation-polymicrogyria syndrome, Cowden syndrome |
| RS121913279 |
PIK3CA
|
Health Risk |
Pathogenic |
Carcinoma of colon, Hepatocellular carcinoma |
| RS121913281 |
PIK3CA
|
Health Risk |
Pathogenic |
Megalencephaly-capillary malformation-polymicrogyria syndrome, Non-small cell lung carcinoma |
| RS121913283 |
PIK3CA
|
Health Risk |
Pathogenic |
Non-small cell lung carcinoma, PIK3CA related overgrowth syndrome |
| RS121913284 |
PIK3CA
|
Health Risk |
Pathogenic |
Abnormal cardiovascular system morphology, 13 conditions |
| RS121913285 |
PIK3CA
|
Health Risk |
Likely pathogenic |
Megalencephaly-capillary malformation-polymicrogyria syndrome, Neoplasm |
| RS121913286 |
PIK3CA
|
Health Risk |
Pathogenic |
Breast adenocarcinoma, PIK3CA related overgrowth syndrome |
| RS121913287 |
PIK3CA
|
Health Risk |
Pathogenic |
Ovarian neoplasm, Cowden syndrome |
| RS121913288 |
PIK3CA
|
Health Risk |
Pathogenic |
Abnormal cardiovascular system morphology, Cowden syndrome |
| RS121913289 |
PTEN
|
Health Risk |
Pathogenic |
PTEN hamartoma tumor syndrome, Hereditary cancer-predisposing syndrome |
| RS121913290 |
PTEN
|
Health Risk |
Pathogenic |
Hereditary cancer-predisposing syndrome, PTEN hamartoma tumor syndrome |
| RS121913291 |
PTEN
|
Health Risk |
Likely pathogenic |
Cowden syndrome 1, PTEN hamartoma tumor syndrome |
| RS121913292 |
PTEN
|
Health Risk |
Pathogenic |
Cowden syndrome 1, PTEN hamartoma tumor syndrome |
| RS121913293 |
PTEN
|
Health Risk |
Pathogenic |
Hereditary cancer-predisposing syndrome, PTEN hamartoma tumor syndrome |
| RS121913294 |
PTEN
|
Health Risk |
Likely pathogenic |
Hereditary cancer-predisposing syndrome, PTEN hamartoma tumor syndrome |
| RS121913295 |
RB1
|
Health Risk |
Pathogenic/Likely pathogenic |
Retinoblastoma, Retinoblastoma |
| RS121913296 |
RB1
|
Health Risk |
Pathogenic |
Retinoblastoma, Hereditary retinoblastoma |
| RS121913297 |
RB1
|
Health Risk |
Pathogenic |
Small cell lung carcinoma, Retinoblastoma |
| RS121913298 |
RB1
|
Health Risk |
Pathogenic |
Retinoblastoma, Retinoblastoma |
| RS121913300 |
RB1
|
Health Risk |
Pathogenic |
Retinoblastoma, Hereditary cancer-predisposing syndrome |
| RS121913301 |
RB1
|
Health Risk |
Pathogenic |
Retinoblastoma, Hereditary cancer-predisposing syndrome |
| RS121913302 |
RB1
|
Health Risk |
Conflicting classifications of pathogenicity |
Retinoblastoma, Hereditary cancer-predisposing syndrome |
| RS1219133025 |
COL11A2
|
Health Risk |
Conflicting classifications of pathogenicity |
Autosomal dominant nonsyndromic hearing loss 13, Autosomal dominant nonsyndromic hearing loss 13 |
| RS121913303 |
RB1
|
Health Risk |
Pathogenic |
Retinoblastoma, Hereditary cancer-predisposing syndrome |
| RS121913304 |
RB1
|
Health Risk |
Pathogenic |
Trilateral retinoblastoma, Retinoblastoma |
| RS121913305 |
RB1
|
Health Risk |
Pathogenic |
Retinoblastoma, Hereditary cancer-predisposing syndrome |
| RS121913307 |
RET
|
Health Risk |
Likely pathogenic |
Multiple endocrine neoplasia type 2B, Multiple endocrine neoplasia type 2B |
| RS121913314 |
SRC
|
Health Risk |
Pathogenic |
Colon cancer, advanced |
| RS121913315 |
STK11
|
Health Risk |
Conflicting classifications of pathogenicity |
Melanoma, cutaneous malignant |
| RS121913317 |
STK11
|
Health Risk |
Pathogenic |
Peutz-Jeghers syndrome, Peutz-Jeghers syndrome |
| RS121913319 |
STK11
|
Health Risk |
Pathogenic/Likely pathogenic |
Hereditary cancer-predisposing syndrome, Peutz-Jeghers syndrome |
| RS121913320 |
STK11
|
Health Risk |
Pathogenic |
Hereditary cancer-predisposing syndrome, Peutz-Jeghers syndrome |
| RS121913321 |
STK11
|
Health Risk |
Pathogenic |
Peutz-Jeghers syndrome, Hereditary cancer-predisposing syndrome |
| RS121913322 |
STK11
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Peutz-Jeghers syndrome |
| RS121913323 |
STK11
|
Health Risk |
Pathogenic |
Melanoma, cutaneous malignant |
| RS121913324 |
STK11
|
Health Risk |
Pathogenic |
Hereditary cancer-predisposing syndrome, Peutz-Jeghers syndrome |
| RS121913326 |
APC
|
Health Risk |
Pathogenic |
Familial adenomatous polyposis 1, Familial adenomatous polyposis 1 |
| RS121913327 |
APC
|
Health Risk |
Pathogenic |
Carcinoma of colon, Familial adenomatous polyposis 1 |
| RS121913328 |
APC
|
Health Risk |
Pathogenic |
Familial adenomatous polyposis 1, Colorectal cancer |
| RS121913329 |
APC
|
Health Risk |
Pathogenic |
Hereditary cancer-predisposing syndrome, Familial adenomatous polyposis 1 |
| RS121913331 |
APC
|
Health Risk |
Pathogenic |
Hereditary cancer-predisposing syndrome, Familial multiple polyposis syndrome |
| RS121913332 |
APC
|
Health Risk |
Pathogenic |
Familial adenomatous polyposis 1, Hereditary cancer-predisposing syndrome |
| RS121913333 |
APC
|
Health Risk |
Pathogenic |
Hereditary cancer-predisposing syndrome, Carcinoma of colon |
| RS121913337 |
BRAF
|
Health Risk |
Likely pathogenic |
Cardio-facio-cutaneous syndrome, Cardio-facio-cutaneous syndrome |
| RS121913338 |
BRAF
|
Health Risk |
Pathogenic |
Non-Hodgkin lymphoma, Non-small cell lung carcinoma |
| RS121913341 |
BRAF
|
Health Risk |
Pathogenic |
Cardio-facio-cutaneous syndrome, RASopathy |
| RS121913343 |
TP53
|
Health Risk |
Pathogenic/Likely pathogenic |
Li-Fraumeni syndrome 1, Prostate cancer |
| RS121913344 |
TP53
|
Health Risk |
Pathogenic |
Hereditary cancer-predisposing syndrome, Li-Fraumeni syndrome |
| RS121913346 |
VHL
|
Health Risk |
Pathogenic |
Von Hippel-Lindau syndrome, Hereditary cancer-predisposing syndrome |
| RS121913348 |
BRAF
|
Health Risk |
Likely pathogenic |
Carcinoma of colon, RASopathy |
| RS121913349 |
BRAF
|
Health Risk |
Pathogenic |
RASopathy, Cardio-facio-cutaneous syndrome |
| RS121913351 |
BRAF
|
Health Risk |
Conflicting classifications of pathogenicity |
Lung adenocarcinoma, Non-small cell lung carcinoma |
| RS121913353 |
BRAF
|
Health Risk |
Pathogenic |
Non-small cell lung carcinoma, Vascular malformation |
| RS121913355 |
BRAF
|
Health Risk |
Pathogenic |
Non-Hodgkin lymphoma, Non-small cell lung carcinoma |
| RS121913357 |
BRAF
|
Health Risk |
Pathogenic/Likely pathogenic |
Non-Hodgkin lymphoma, Cardio-facio-cutaneous syndrome |
| RS121913361 |
BRAF
|
Health Risk |
Conflicting classifications of pathogenicity |
Noonan syndrome and Noonan-related syndrome, RASopathy |
| RS121913364 |
BRAF
|
Health Risk |
Pathogenic |
Thyroid cancer, nonmedullary |
| RS121913366 |
BRAF
|
Health Risk |
Pathogenic |
Lung adenocarcinoma, Neuroblastoma |
| RS121913369 |
BRAF
|
Health Risk |
Conflicting classifications of pathogenicity |
Non-small cell lung carcinoma, Noonan syndrome 7 |
| RS121913370 |
BRAF
|
Health Risk |
Likely pathogenic |
Non-small cell lung carcinoma, Lung adenocarcinoma |
| RS121913375 |
BRAF
|
Health Risk |
Pathogenic |
Noonan syndrome, RASopathy |
| RS121913376 |
BRAF
|
Health Risk |
Likely pathogenic |
RASopathy, Ataxia-telangiectasia syndrome |
| RS121913378 |
BRAF
|
Health Risk |
Pathogenic/Likely pathogenic |
Non-small cell lung carcinoma, Non-small cell lung carcinoma |
| RS121913381 |
CDKN2A
|
Health Risk |
Conflicting classifications of pathogenicity |
Hereditary cancer-predisposing syndrome, Familial melanoma |