Genetic variant
rs9989419
rs9989419 is a single-letter difference in human DNA, on chromosome 16. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs9989419 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs9989419, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs9989419
- Position
- chr16:56951227
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| HDL cholesterol levels | A | OR 0.14 | 1E-1211 | PubMed |
| Apolipoprotein A1 levels | A | OR 0.11 | 6E-724 | PubMed |
| high density lipoprotein cholesterol (HDLC, mean, inv-norm transformed) | A | OR 0.14 | 1E-323 | PubMed |
| high density lipoprotein cholesterol (HDLC, maximum, inv-norm transformed) | A | OR 0.14 | 1E-323 | PubMed |
| high density lipoprotein cholesterol (HDLC, minimm, inv-norm transformed) | A | OR 0.14 | 1E-323 | PubMed |
| HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) | G | — | 6E-299 | PubMed |
| High density lipoprotein cholesterol levels | A | OR 0.12 | 1E-266 | PubMed |
| HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) | G | — | 3E-225 | PubMed |
| Phospholipids in large HDL (UKB data field 23560) | A | OR 0.13 | 1E-200 | PubMed |
| Cholesteryl esters in large HDL (UKB data field 23562) | A | OR 0.14 | 1E-200 | PubMed |
| Free cholesterol to total lipids in very large HDL percentage (UKB data field 23632) | A | OR 0.13 | 1E-200 | PubMed |
| Free cholesterol to total lipids in medium HDL percentage (UKB data field 23642) | A | OR 0.14 | 1E-200 | PubMed |
| Cholesterol in large HDL (UKB data field 23561) | A | OR 0.14 | 1E-200 | PubMed |
| Total lipids in large HDL (UKB data field 23559) | A | OR 0.13 | 1E-200 | PubMed |
| HDL cholesterol levels (UKB data field 23406) | A | OR 0.14 | 1E-200 | PubMed |
| Cholesteryl esters in HDL (UKB data field 23418) | A | OR 0.14 | 1E-200 | PubMed |
| Concentration of large HDL particles (UKB data field 23558) | A | OR 0.14 | 1E-200 | PubMed |
| HDL cholesterol levels in current drinkers | G | β 0.027 | 1E-172 | PubMed |
| HDL cholesterol levels | A | β 0.032 | 8E-133 | PubMed |
| Multi-trait sex score | — | — | 3E-95 | PubMed |
Sources
- dbSNP: rs9989419 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies