Genetic variant
rs9939224
rs9939224 is a single-letter difference in human DNA, on chromosome 16. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs9939224 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs9939224, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs9939224
- Position
- chr16:56968820
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| High density lipoprotein cholesterol levels | G | OR 0.25 | 2E-1466 | PubMed |
| Apolipoprotein A1 levels | G | OR 0.19 | 3E-878 | PubMed |
| Triglyceride to HDL cholesterol ratio | G | OR 0.11 | 3E-308 | PubMed |
| High density lipoprotein cholesterol levels | — | OR 0.19 | 1E-97 | PubMed |
| Apolipoprotein B levels | G | β 0.05 | 6E-67 | PubMed |
| Total cholesterol levels | G | β 0.043 | 6E-50 | PubMed |
| HDL cholesterol levels | G | OR 0.2 | 1E-47 | PubMed |
| Metabolic dysfunction-associated steatotic liver disease (MTAG) | T | β 0.068 | 1E-41 | PubMed |
| Triglyceride levels (MTAG) | T | β 0.041 | 6E-41 | PubMed |
| Low density lipoprotein cholesterol levels | G | β 0.037 | 2E-37 | PubMed |
| Omega-6 fatty acid levels | T | — | 3E-36 | PubMed |
| Multi-trait sum score | — | — | 8E-30 | PubMed |
| Triglyceride levels | G | β 0.033 | 2E-29 | PubMed |
| Docosahexaenoic acid levels | T | — | 2E-19 | PubMed |
| Lysophosphatidylcholine_16:0_[M+H]1+/Lysophosphatidylethanolamine_19:0_[M+H]1+ levels | T | β 0.097 | 1E-16 | PubMed |
| Postprandial total cholesterol in HDL2 | G | OR 0.22 | 2E-16 | PubMed |
| Phosphatidylcholine-O_18:0_[M+H]1+/Lysophosphatidylethanolamine_21:0_[M+H]1+ levels | T | OR 0.1 | 1E-15 | PubMed |
| Fasting cholesterol esters in medium HDL | G | OR 0.2 | 3E-15 | PubMed |
| Fasting total cholesterol in medium HDL | G | OR 0.2 | 2E-14 | PubMed |
| Postprandial cholesterol esters in medium HDL | G | OR 0.21 | 4E-14 | PubMed |
Sources
- dbSNP: rs9939224 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies