Genetic variant
rs9898
rs9898 is a single-letter difference in human DNA, on chromosome 3. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs9898 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
KNG1 Ile581Thr and susceptibility to venous thrombosis. [OMIM:HISTIDINE-RICH GLYCOPROTEIN
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs9898, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs9898
- Position
- chr3:186672838
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Histidine-rich glycoprotein levels | — | OR 0.81 | 6E-268 | PubMed |
| HRG protein levels | — | OR 0.98 | 8E-232 | PubMed |
| Histidine-rich glycoprotein levels | T | OR 0.81 | 2E-185 | PubMed |
| CDKL3 protein levels | — | OR 0.82 | 3E-147 | PubMed |
| Activated partial thromboplastin time | C | OR 1 | 1E-111 | PubMed |
| Histidine-rich glycoprotein levels | T | OR 0.48 | 1E-89 | PubMed |
| Protein DEPP levels | T | OR 0.44 | 3E-72 | PubMed |
| Dual specificity mitogen-activated protein kinase kinase 4 levels | T | OR 0.39 | 2E-60 | PubMed |
| Serum levels of protein MAP2K4 | T | OR 0.29 | 7E-45 | PubMed |
| Persulfide dioxygenase ETHE1, mitochondrial levels | T | OR 0.37 | 7E-41 | PubMed |
| Latexin levels | T | OR 0.32 | 2E-32 | PubMed |
| PLG protein levels | T | β 0.058 | 5E-23 | PubMed |
| Persulfide dioxygenase ETHE1, mitochondrial levels | — | OR 0.27 | 2E-22 | PubMed |
| CD27 antigen level in Chronic kidney disease with hypertension and no diabetes (5412_53) | T | OR 0.54 | 2E-19 | PubMed |
| Protein quantitative trait loci | — | — | 4E-18 | PubMed |
| PLMN protein level (protein group normalized intensity) | T | OR 0.3 | 8E-17 | PubMed |
| Dual specificity mitogen-activated protein kinase kinase 4 level in Chronic kidney disease with hypertension and no diabetes (5242_37) | T | OR 0.48 | 9E-15 | PubMed |
| Aspartate aminotransferase levels | T | β 0.011 | 6E-13 | PubMed |
| Activated partial thromboplastin time | T | OR 0.26 | 1E-11 | PubMed |
| Cerebrospinal fluid biomarker levels | — | — | 5E-10 | PubMed |
Sources
- dbSNP: rs9898 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies