Genetic variant
rs9330813
rs9330813 is a single-letter difference in human DNA, on chromosome 22. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs9330813 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Family-Based Genome-Wide Association Study of South Indian Pedigrees Supports WNT7B as a Central Corneal Thickness Locus.
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs9330813, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs9330813
- Position
- chr22:45968281
Genome-wide association studies (16)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Hemoglobin concentration | A | — | 1E-53 | PubMed |
| Red blood cell count | — | — | 2E-47 | PubMed |
| Hemoglobin | A | β 0.025 | 2E-45 | PubMed |
| Retinal thickness (pixel 42_218) | A | OR 0.4 | 1E-33 | PubMed |
| Age-related eyesight deterioration (confirmatory factor analysis Factor 27) | — | — | 8E-28 | PubMed |
| Hematocrit | A | β 0.034 | 9E-19 | PubMed |
| Hemoglobin concentration | A | β 0.034 | 2E-17 | PubMed |
| Red blood cell count | A | β 0.031 | 3E-16 | PubMed |
| Appendicular lean mass | A | β 0.016 | 7E-15 | PubMed |
| Spherical equivalent | G | β 0.09 | 5E-14 | PubMed |
| Male-pattern baldness | A | β 0.024 | 1E-12 | PubMed |
| Optic disc size | A | β 0.01 | 1E-9 | PubMed |
| Pancreas volume | — | β 0.049 | 1E-9 | PubMed |
| Physical function (baseline) | G | β 0.007 | 7E-9 | PubMed |
| Body size (confirmatory factor analysis Factor 21) | — | — | 1E-8 | PubMed |
| Central corneal thickness | A | OR 17.18 | 2E-7 | PubMed |
Sources
- dbSNP: rs9330813 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies