Genetic variant
rs9273363
rs9273363 is a single-letter difference in human DNA, on chromosome 6. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs9273363 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
This is one of the SNPs that 23andMe uses for Type 1 diabetes. According to 23andMe, this SNP change...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs9273363, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs9273363
- Position
- chr6:32658495
Genome-wide association studies (17)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| CD74/IL18BP protein level ratio | — | OR 0.21 | 2E-183 | PubMed |
| CD74/DLL1 protein level ratio | — | OR 0.21 | 5E-176 | PubMed |
| CD74/JAM2 protein level ratio | — | OR 0.2 | 4E-166 | PubMed |
| CD74/NPDC1 protein level ratio | — | OR 0.2 | 2E-160 | PubMed |
| Type 1 diabetes | A | OR 5.48 | 5E-138 | PubMed |
| Type 1 diabetes (PheCode 250.1) | C | OR 0.24 | 2E-92 | PubMed |
| Type 1 diabetes with ketoacidosis (PheCode 250.11) | C | OR 0.96 | 2E-64 | PubMed |
| Type 1 diabetes (PheCode 250.1) | — | — | 3E-43 | PubMed |
| Seropositivity for streptococcus pneumoniae peptide (agilent_242450) | — | OR 10.21 | 2E-24 | PubMed |
| Seropositivity for streptococcus pneumoniae peptide (agilent_226736) | — | OR 9.25 | 2E-20 | PubMed |
| Type 1 diabetes with ketoacidosis (PheCode 250.11) | C | OR 1.03 | 1E-17 | PubMed |
| Monounsaturated fatty acid levels | A | — | 4E-13 | PubMed |
| Takes medication for Diabetes/sugar? | C | β 0.052 | 4E-11 | PubMed |
| Chronic lymphocytic leukemia | A | OR 1.24 | 2E-10 | PubMed |
| Total fatty acid levels | A | — | 4E-10 | PubMed |
| Seropositivity for streptococcus pneumoniae peptide (agilent_223466) | — | OR 6.14 | 8E-10 | PubMed |
| Gastroparesis | A | OR 1.4 | 1E-7 | PubMed |
Sources
- dbSNP: rs9273363 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies