Genetic variant
rs9264942 a variant in the LOC112267902 gene
rs9264942 is a single-letter difference in the LOC112267902 gene, on chromosome 6. ClinVar, the public archive of variant interpretations, lists it as risk factor: linked to a somewhat higher chance of a condition, not a cause on its own. It has been reported in connection with Hiv-1 viremia and Susceptibility to. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs9264942 is the catalogue number of one of them, in the LOC112267902 gene. Which letters you carry there — one copy from each parent — is your genotype.
This SNP (C/T) is in 5' region of the HLA-C gene, 35 kb away from transcription initiation in or aro...
From SNPedia
Why might it matter?
ClinVar records this variant as risk factor, meaning linked to a somewhat higher chance of a condition, not a cause on its own. A classification describes the variant, not you: what it means for one person depends on their genotype, their family history and often on other genes and circumstances.
Conditions it has been reported with
- Hiv-1 viremia
- Susceptibility to
Listed in ClinVar submissions for this variant. Being listed is a report of an association, not a statement that the variant causes the condition in any given person.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs9264942, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs9264942
- Gene
- LOC112267902
- Position (GRCh38)
- chr6:31306602
- Variant type
- snv
- Consequence
- intron variant
- ClinVar classification
- risk factor
Genome-wide association studies (7)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| HIV-1 control | C | OR 2.9 | 3E-35 | PubMed |
| HIV-1 control | C | OR 5.3 | 6E-32 | PubMed |
| CRTAM/VCAM1 protein level ratio | — | β 0.08 | 4E-29 | PubMed |
| Crohn's disease | C | OR 1.15 | 5E-28 | PubMed |
| Crohn's disease | — | — | 5E-25 | PubMed |
| MHC class I polypeptide-related sequence A levels | C | OR 0.27 | 1E-20 | PubMed |
| LILRA5 protein levels | C | β 0.039 | 1E-12 | PubMed |
ClinVar submissions (4)
How common the less frequent letter is
- 1kG AFR
- 73%
- 1kG ALL
- 36.8%
- 1kG AMR
- 30.4%
- 1kG EAS
- 60.7%
- 1kG EUR
- 63.8%
- 1kG SAS
- 52.5%
Sources
- dbSNP: rs9264942 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies