Genetic variant
rs925489
rs925489 is a single-letter difference in human DNA, on chromosome 9. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs925489 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Highest association to hypothyroidism in 23andMe cohort based , association found also in the first ...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs925489, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs925489
- Position
- chr9:97784318
Genome-wide association studies (11)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Hypothyroidism | T | OR 0.25 | 6E-953 | PubMed |
| Autoimmune thyroid disease | T | OR 1.25 | 9E-110 | PubMed |
| Hypothyroidism | T | OR 0.2 | 4E-92 | PubMed |
| Autoimmune thyroid disease | C | OR 0.82 | 7E-77 | PubMed |
| Thyroid cancer | T | OR 0.56 | 9E-35 | PubMed |
| Acquired hypothyroidism (PheCode 244.2) | C | OR 0.21 | 3E-24 | PubMed |
| Hypothyroidism | T | OR 1.28 | 2E-19 | PubMed |
| Serum thyroid-stimulating hormone levels | C | β 0.058 | 1E-13 | PubMed |
| Thyroid cancer (PheCode 193) | T | — | 5E-11 | PubMed |
| Atrial fibrillation | C | OR 1.03 | 2E-10 | PubMed |
| Benign nodular goiter | T | OR 0.12 | 5E-9 | PubMed |
Sources
- dbSNP: rs925489 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies