Genetic variant
rs855791
rs855791 is a single-letter difference in human DNA, on chromosome 22. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs855791 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
rs855791, also known as V736A, is a SNP in the transmembrane protease, serine 6 TMPRSS6 gene. 2 stud...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs855791, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs855791
- Position
- chr22:37066896
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Mean corpuscular hemoglobin | G | OR 0.14 | 8E-1100 | PubMed |
| Mean corpuscular volume | G | OR 0.12 | 9E-761 | PubMed |
| Mean corpuscular hemoglobin | G | OR 0.15 | 8E-718 | PubMed |
| Mean corpuscular volume | A | OR 0.59 | 3E-610 | PubMed |
| Hemoglobin concentration | G | OR 0.1 | 1E-605 | PubMed |
| Red cell distribution width | G | OR 0.11 | 5E-420 | PubMed |
| Mean corpuscular volume | G | OR 0.15 | 1E-407 | PubMed |
| Hemoglobin | G | β 0.067 | 3E-373 | PubMed |
| Hemoglobin | G | β 0.092 | 8E-327 | PubMed |
| hemoglobin (maximum, inv-norm transformed) | A | OR 0.1 | 1E-323 | PubMed |
| red cell diameter width (RDW, maximum, inv-norm transformed) | A | OR 0.11 | 1E-323 | PubMed |
| Hematocrit | G | — | 1E-311 | PubMed |
| Iron status biomarkers (iron levels) | A | OR 0.17 | 1E-300 | PubMed |
| Iron status biomarkers (transferrin saturation) | A | OR 0.17 | 1E-300 | PubMed |
| Hematocrit | G | β 0.069 | 4E-284 | PubMed |
| Mean corpuscular hemoglobin concentration | A | β 0.095 | 7E-278 | PubMed |
| Mean corpuscular hemoglobin concentration | G | β 0.069 | 4E-260 | PubMed |
| hemoglobin (mean, inv-norm transformed) | A | β 0.087 | 2E-255 | PubMed |
| iron (mean, inv-norm transformed) | A | OR 0.15 | 2E-252 | PubMed |
| iron (maximum, inv-norm transformed) | A | OR 0.15 | 3E-245 | PubMed |
Sources
- dbSNP: rs855791 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies