Genetic variant
rs846111
rs846111 is a single-letter difference in human DNA, on chromosome 1. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs846111 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
23andMe blog Influences QT interval [GWAS:QT interval]
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs846111, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs846111
- Position
- chr1:6219310
Genome-wide association studies (19)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| JT interval | C | OR 0.1 | 2E-202 | PubMed |
| QT interval | C | β 0.099 | 3E-186 | PubMed |
| QT interval | C | OR 1.73 | 7E-40 | PubMed |
| ECG latent space | — | — | 2E-38 | PubMed |
| ECG cardiac MRI latent space | — | — | 2E-36 | PubMed |
| QT interval | G | β 0.067 | 7E-25 | PubMed |
| Electrocardiogram morphology (amplitude at temporal datapoints) | G | β 0.06 | 8E-23 | PubMed |
| QT interval | G | β 0.057 | 8E-18 | PubMed |
| QT interval | C | OR 1.75 | 1E-16 | PubMed |
| QT interval | C | OR 1.49 | 4E-16 | PubMed |
| Atrial fibrillation | C | β 0.029 | 8E-15 | PubMed |
| Atrial fibrillation | C | β 0.029 | 8E-14 | PubMed |
| Cardiac pacemaker in situ (PheCode 426.91) | G | β 0.088 | 2E-13 | PubMed |
| Cardiac pacemaker in situ (PheCode 426.91) | G | β 0.087 | 2E-12 | PubMed |
| Electrocardiographic traits (multivariate) | — | — | 1E-11 | PubMed |
| QT interval | — | OR 1.92 | 2E-11 | PubMed |
| Hypertrophic cardiomyopathy (sarcomere-negative) | G | OR 0.22 | 1E-10 | PubMed |
| Heart failure (multivariate analysis) | — | β 0.015 | 6E-9 | PubMed |
| Hypertrophic cardiomyopathy (sarcomere negative) | G | OR 0.26 | 6E-7 | PubMed |
Sources
- dbSNP: rs846111 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies