Genetic variant
rs838133
rs838133 is a single-letter difference in human DNA, on chromosome 19. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs838133 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
A 2017 study of ~6,500 individuals with detailed eating records concluded that the rs838133(T) allel...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs838133, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs838133
- Position
- chr19:48756272
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Urea levels (UKB data field 30670) | G | β 0.038 | 2E-82 | PubMed |
| Blood urea nitrogen levels | G | β 0.041 | 2E-66 | PubMed |
| Human milk oligosaccharide concentration (2'-fucosyllactose) | A | OR 15.64 | 4E-55 | PubMed |
| Degree of unsaturation | G | β 0.03 | 6E-52 | PubMed |
| Human milk oligosaccharide concentration (Fucose-bound) | A | OR 15.11 | 1E-51 | PubMed |
| Polyunsaturated fatty acids to total fatty acids percentage | G | β 0.03 | 4E-49 | PubMed |
| Drinks per week | G | β 0.012 | 8E-48 | PubMed |
| Human milk oligosaccharide concentration (lacto-N-fucopentaose-I) | A | OR 14.1 | 4E-45 | PubMed |
| Triglycerides in HDL | G | β 0.03 | 2E-42 | PubMed |
| Triglycerides in very small VLDL | G | β 0.03 | 3E-42 | PubMed |
| Human milk oligosaccharide concentration (difucosyllactose) | A | OR 13.52 | 1E-41 | PubMed |
| Polyunsaturated fatty acids to monounsaturated fatty acids ratio | G | β 0.03 | 8E-40 | PubMed |
| Total concentration of 19 human milk oligosaccharides | A | OR 13.1 | 3E-39 | PubMed |
| Human milk oligosaccharide concentration (lacto-N-fucopentaose-II) | A | OR 12.99 | 1E-38 | PubMed |
| Triglycerides in medium HDL | G | β 0.03 | 5E-38 | PubMed |
| Triglyceride levels | — | — | 1E-37 | PubMed |
| F-sweet food liking (derived food-liking factor) | G | β 0.046 | 1E-36 | PubMed |
| Triglycerides in very large HDL | G | β 0.03 | 6E-36 | PubMed |
| Triglycerides in large HDL | G | β 0.02 | 9E-36 | PubMed |
| F-cake/biscuits liking (derived food-liking factor) | G | OR 0.14 | 2E-35 | PubMed |
Sources
- dbSNP: rs838133 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies