Genetic variant
rs8176722
rs8176722 is a single-letter difference in human DNA, on chromosome 9. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs8176722 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs8176722, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs8176722
- Position
- chr9:133257367
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Cadherin-5 levels | A | OR 1.01 | 3E-139 | PubMed |
| Immunoglobulin superfamily containing leucine-rich repeat protein 2 levels | — | OR 0.7 | 3E-80 | PubMed |
| Cadherin-5 level in Chronic kidney disease with hypertension and no diabetes (2819_23) | A | OR 1.28 | 5E-68 | PubMed |
| Roundabout homolog 4 level in Chronic kidney disease with hypertension and no diabetes (9232_1) | A | OR 1.24 | 7E-63 | PubMed |
| Endoglin levels | — | OR 0.61 | 6E-62 | PubMed |
| red blood cell count (RBC, maximum, inv-norm transformed) | C | β 0.098 | 1E-49 | PubMed |
| Tyrosine-protein kinase receptor Tie-1, soluble level in Chronic kidney disease with hypertension and no diabetes (2844_53) | A | OR 1.13 | 4E-47 | PubMed |
| Basal Cell Adhesion Molecule levels | A | OR 0.57 | 6E-46 | PubMed |
| Other venous embolism and thrombosis (PheCode 452) | C | OR 0.31 | 9E-42 | PubMed |
| red blood cell count (RBC, mean, inv-norm transformed) | C | β 0.088 | 3E-41 | PubMed |
| Deep vein thrombosis [DVT] (PheCode 452.2) | C | OR 0.36 | 9E-36 | PubMed |
| hemoglobin (maximum, inv-norm transformed) | C | β 0.068 | 4E-31 | PubMed |
| Angiopoietin-1 receptor, soluble level in Chronic kidney disease with hypertension and no diabetes (3773_15) | A | OR 0.92 | 7E-28 | PubMed |
| red blood cell count (RBC, minimum, inv-norm transformed) | C | β 0.067 | 3E-26 | PubMed |
| hemoglobin (mean, inv-norm transformed) | C | β 0.057 | 8E-26 | PubMed |
| Leukemia inhibitory factor receptor levels | — | OR 0.37 | 5E-25 | PubMed |
| monocyte (fraction, mean, inv-norm transformed) | C | β 0.052 | 2E-24 | PubMed |
| Immunoglobulin superfamily containing leucine-rich repeat protein 2 level in Chronic kidney disease with hypertension and no diabetes (8528_74) | A | OR 0.85 | 2E-22 | PubMed |
| Immunoglobulin superfamily containing leucine-rich repeat protein 2 level in Chronic kidney disease with hypertension and no diabetes (13124_20) | A | OR 0.83 | 4E-22 | PubMed |
| Interleukin-3 receptor subunit alpha level in Chronic kidney disease with hypertension and no diabetes (13744_37) | A | OR 0.81 | 5E-21 | PubMed |
Sources
- dbSNP: rs8176722 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies