RS8099917 IFNL3

Drug Response Chr 19:39252524 snv intergenic variant

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What This Variant Does

"23andMe blog rs8099917(C) less likely to respond to Hepatitis C treatment. rs12979860(C

Associated Conditions

interferons

peginterferon alfa-2a

peginterferon alfa-2b

and ribavirin response - Efficacy

ribavirin

and telaprevir response - Efficacy

interferons

peginterferon alfa-2a

peginterferon alfa-2b

and ribavirin response - Efficacy

ribavirin

and telaprevir response - Efficacy

GWAS Studies (4)

Trait	Risk Allele	OR / Beta	P-value	Study
Response to hepatitis C treatment	G	OR: 27.1	3E-32	PubMed
Response to hepatitis C treatment	G	OR: 3	1E-20	PubMed
Chronic hepatitis C infection	G	OR: 2.31	6E-9	PubMed
Response to hepatitis C treatment	G	OR: 1.98	9E-9	PubMed

Population Frequencies

1kG AFR

95.8%

1kG ALL

86.9%

1kG AMR

27.7%

1kG EAS

92.4%

1kG EUR

16.8%

1kG SAS

16.7%

Other Variants in IFNL3