Genetic variant
rs8050136
rs8050136 is a single-letter difference in human DNA, on chromosome 16. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs8050136 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
This SNP is in a linkage block in the FTO gene with rs1121980
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs8050136, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs8050136
- Position
- chr16:53782363
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Type 2 diabetes or polycystic ovary syndrome (pleiotropy) | A | — | 2E-85 | PubMed |
| Body mass index | A | β 0.084 | 2E-58 | PubMed |
| Body mass index (joint analysis main effects and physical activity interaction) | — | — | 4E-54 | PubMed |
| Body mass index | A | OR 8.04 | 1E-47 | PubMed |
| Type 2 diabetes | A | OR 0.11 | 3E-39 | PubMed |
| Body mass index in physically active individuals | A | β 0.079 | 4E-39 | PubMed |
| Weight | A | OR 7.05 | 5E-36 | PubMed |
| Adiposity | C | β 0.06 | 3E-26 | PubMed |
| Blood urea nitrogen levels | A | β 0.007 | 3E-23 | PubMed |
| Body fat percentage or coronary artery disease (MTAG) | — | β 0.027 | 4E-19 | PubMed |
| Body mass index in physically inactive individuals | A | β 0.093 | 2E-18 | PubMed |
| Type 2 diabetes | — | OR 1.3 | 2E-17 | PubMed |
| Menarche (age at onset) | C | β 0.04 | 2E-17 | PubMed |
| Body mass index | — | β 0.056 | 7E-17 | PubMed |
| Type 2 diabetes | A | OR 1.23 | 7E-14 | PubMed |
| Type 2 diabetes | A | OR 1.17 | 1E-12 | PubMed |
| Pulse pressure (BMI unadjusted) | A | OR 0.64 | 9E-11 | PubMed |
| Urate levels | A | β 0.025 | 2E-10 | PubMed |
| Obesity (extreme) | A | OR 1.51 | 8E-10 | PubMed |
| Body mass in chronic obstructive pulmonary disease | A | — | 4E-8 | PubMed |
Sources
- dbSNP: rs8050136 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies