Genetic variant
rs7896518
rs7896518 is a single-letter difference in human DNA, on chromosome 10. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs7896518 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs7896518, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs7896518
- Position
- chr10:63344740
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Mitochondrial DNA copy number | G | β 0.046 | 1E-98 | PubMed |
| GP1BB protein levels | G | β 0.092 | 4E-56 | PubMed |
| SIAE protein levels | G | β 0.087 | 3E-53 | PubMed |
| Platelet distribution width (UKB data field 30110) | G | β 0.028 | 7E-53 | PubMed |
| TREML1 protein levels | G | β 0.078 | 2E-39 | PubMed |
| Dickkopf-related protein 1 levels | A | OR 0.11 | 6E-39 | PubMed |
| ADGRF5 protein levels | G | β 0.07 | 9E-36 | PubMed |
| ZFYVE19 protein levels | G | β 0.066 | 8E-32 | PubMed |
| STXBP1 protein levels | G | β 0.071 | 4E-31 | PubMed |
| FKBP1B protein levels | G | β 0.066 | 7E-30 | PubMed |
| CCL11 protein levels | G | β 0.056 | 2E-27 | PubMed |
| DNM1 protein levels | G | β 0.062 | 2E-26 | PubMed |
| Platelet distribution width | G | β 0.024 | 5E-25 | PubMed |
| BRK1 protein levels | G | β 0.059 | 3E-24 | PubMed |
| Platelet count | — | OR 5.51 | 1E-23 | PubMed |
| High-density lipoprotein levels (MTAG) | A | β 0.026 | 5E-23 | PubMed |
| Sum basophil neutrophil counts | G | β 0.036 | 1E-22 | PubMed |
| Myeloid white cell count | G | β 0.035 | 6E-21 | PubMed |
| ARHGAP1 protein levels | G | β 0.057 | 7E-21 | PubMed |
| RAB27B protein levels | G | β 0.055 | 3E-19 | PubMed |
Sources
- dbSNP: rs7896518 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies