Genetic variant
rs7841189
rs7841189 is a single-letter difference in human DNA, on chromosome 8. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs7841189 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs7841189, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs7841189
- Position
- chr8:19987865
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Cholesteryl Esters in Small HDL | T | OR 0.12 | 4E-138 | PubMed |
| Cholesterol in Small HDL | T | OR 0.1 | 1E-105 | PubMed |
| Concentration of small HDL particles | T | β 0.081 | 2E-64 | PubMed |
| Familial combined hyperlipidemia defined by Mexico criteria | C | OR 0.42 | 6E-34 | PubMed |
| HDL cholesterol levels | T | OR 0.17 | 2E-30 | PubMed |
| Cholesteryl Esters in Small HDL | T | β 0.042 | 2E-22 | PubMed |
| Total lipids in small HDL | T | β 0.043 | 1E-19 | PubMed |
| Phospholipids in small HDL | T | β 0.039 | 2E-16 | PubMed |
| Cholesterol in Small HDL | T | β 0.035 | 5E-16 | PubMed |
| Sphingomyelin_38:1_[M+H]1+ levels | T | OR 0.14 | 4E-15 | PubMed |
| Metabolic syndrome | C | OR 0.18 | 1E-14 | PubMed |
| Sphingomyelin_36:0_[M+H]1+ levels | T | OR 0.13 | 2E-14 | PubMed |
| Sphingomyelin_36:1_[M+H]1+ levels | T | OR 0.14 | 3E-14 | PubMed |
| Diacylglycerol_44:7_[M+H-H2O]1+ levels | T | OR 0.13 | 2E-13 | PubMed |
| Sphingomyelin_34:1_[M+H]1+ levels | T | OR 0.13 | 3E-13 | PubMed |
| Sphingomyelin_34:0_[M+H]1+ levels | T | OR 0.13 | 3E-13 | PubMed |
| Phosphatidylcholine-O_32:1_[M+H]1+/Phosphatidylcholine-P_32:0_[M+H]1+/Phosphatidylethanolamine-O_35:1_[M+H]1+ levels | T | OR 0.13 | 4E-13 | PubMed |
| Diacylglycerol_34:2_[M+H-H2O]1+ levels | T | OR 0.12 | 5E-13 | PubMed |
| Triacylglycerol_46:5_[M+NH4]1+ levels | T | OR 0.15 | 8E-13 | PubMed |
| Sphingomyelin_40:2_[M+H]1+ levels | T | OR 0.15 | 2E-12 | PubMed |
Sources
- dbSNP: rs7841189 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies