Genetic variant
rs7776054
rs7776054 is a single-letter difference in human DNA, on chromosome 6. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs7776054 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs7776054, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs7776054
- Position
- chr6:135097778
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Mean corpuscular hemoglobin | G | OR 0.22 | 1E-628 | PubMed |
| Mean corpuscular volume | G | OR 0.2 | 1E-560 | PubMed |
| Red blood cell count | G | OR 0.19 | 1E-469 | PubMed |
| Mean corpuscular hemoglobin | — | OR 0.19 | 1E-376 | PubMed |
| Hematocrit | G | β 0.078 | 4E-303 | PubMed |
| Platelet-to-lymphocyte ratio | A | — | 1E-240 | PubMed |
| Plateletcrit | G | OR 0.14 | 5E-233 | PubMed |
| Platelet count | G | OR 0.12 | 4E-181 | PubMed |
| EPO protein levels | G | OR 0.18 | 1E-179 | PubMed |
| Hemoglobin levels | A | β 0.038 | 1E-176 | PubMed |
| Red blood cell forward scatter | G | OR 0.21 | 2E-151 | PubMed |
| White blood cell count | G | — | 2E-138 | PubMed |
| Red cell distribution width | G | β 0.095 | 1E-122 | PubMed |
| Mean corpuscular volume | — | — | 4E-119 | PubMed |
| Mean corpuscular hemoglobin concentration | G | β 0.091 | 2E-118 | PubMed |
| White blood cell count | G | β 0.047 | 2E-110 | PubMed |
| Hemoglobin levels | G | β 0.048 | 3E-84 | PubMed |
| Monocyte count | G | — | 1E-80 | PubMed |
| Total cholesterol levels | — | — | 4E-80 | PubMed |
| Lymphocyte count | G | β 0.04 | 1E-77 | PubMed |
Sources
- dbSNP: rs7776054 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies