RS776746 CYP3A5
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What This Variant Does
"rs776746, also known as 6986A>
Associated Conditions
Hypertension
salt-sensitive essential
susceptibility to
Tacrolimus response
refractory myasthenia gravis
Hypertension
salt-sensitive essential
susceptibility to
Tacrolimus response
refractory myasthenia gravis
GWAS Studies (13)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| X-12063 levels | T | OR: 0.99 | 2E-546 | PubMed |
| Metabolonic lactone sulfate levels | C | OR: 0.93 | 6E-218 | PubMed |
| X-26109 levels | C | OR: 1.09 | 2E-182 | PubMed |
| Urine X-24353 levels in chronic kidney disease | T | OR: 0.8 | 5E-149 | PubMed |
| Plasma metabolonic lactone sulfate levels in chronic kidney disease | T | OR: 1.07 | 2E-135 | PubMed |
| Plasma X-26109 levels in chronic kidney disease | T | OR: 0.97 | 3E-52 | PubMed |
| Eicosanoid 11-dehydro-2,3-dinor-TXB2 b levels | — | OR: 0.35 | 4E-46 | PubMed |
| Tacrolimus trough concentration in kidney transplant patients | — | OR: 0.45 | 5E-35 | PubMed |
| Oxylipin levels (345.2431_0.351) | — | OR: 0.19 | 6E-34 | PubMed |
| Urinary metabolite levels in chronic kidney disease | T | OR: 0.78 | 9E-30 | PubMed |
| Urinary metabolite modules (eigenmetabolites) in chronic kidney disease | T | β: 0.015 | 3E-18 | PubMed |
| Tacrolimus trough concentration in kidney transplant patients | T | OR: 0.13 | 1E-15 | PubMed |
| Tacrolimus trough level in transplant patients (heart, kidney, lung, and liver) | — | OR: 1.74 | 1E-12 | PubMed |
Population Frequencies
gnomAD ALL
9.8%
1kG AFR
82%
1kG ALL
62.1%
1kG AMR
79.7%
1kG EAS
71.3%
1kG EUR
5.7%
1kG SAS
66.8%