Genetic variant
rs7756992
rs7756992 is a single-letter difference in human DNA, on chromosome 6. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs7756992 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Polycystic Kidney disease rs7756992 significantly p = 0.0363 associated with type-2 diabetes in 1,63...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs7756992, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs7756992
- Position
- chr6:20679478
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Type 2 diabetes | G | OR 0.12 | 6E-128 | PubMed |
| Type 2 diabetes | G | OR 1.15 | 2E-88 | PubMed |
| Diabetes / "Sugar" | A | OR 0.1 | 2E-69 | PubMed |
| Type 2 diabetes | G | OR 0.13 | 6E-62 | PubMed |
| Type 2 diabetes | G | OR 1.17 | 7E-35 | PubMed |
| Type 2 diabetes | — | — | 5E-31 | PubMed |
| Type 2 diabetes | G | OR 1.2 | 2E-26 | PubMed |
| Birth weight (MTAG) | A | β 0.043 | 3E-25 | PubMed |
| Biological Mother: Diabetes / "Sugar" | A | β 0.074 | 4E-22 | PubMed |
| Sodium (mean, inv-norm transformed) | A | β 0.027 | 3E-21 | PubMed |
| Psoriasis or type 2 diabetes (trans-disease meta-analysis) | G | OR 1.11 | 2E-20 | PubMed |
| chloride (mean, inv-norm transformed) | A | β 0.027 | 2E-20 | PubMed |
| Birth length (MTAG) | A | β 0.059 | 1E-19 | PubMed |
| chloride (minimum, inv-norm transformed) | A | β 0.024 | 4E-17 | PubMed |
| Systolic blood pressure | A | OR 0.21 | 4E-17 | PubMed |
| low density lipoprotein cholesterol (LDLC, minimum, inv-norm transformed) | A | β 0.021 | 1E-13 | PubMed |
| Systolic blood pressure | A | OR 0.21 | 2E-12 | PubMed |
| Glycated hemoglobin levels | G | β 0.012 | 3E-12 | PubMed |
| low density lipoprotein cholesterol (LDLC, mean, inv-norm transformed) | A | β 0.019 | 7E-12 | PubMed |
| Glucose (finger stick, mean, inv-norm transformed) | A | β 0.034 | 1E-11 | PubMed |
Sources
- dbSNP: rs7756992 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies