Genetic variant
rs7741021
rs7741021 is a single-letter difference in human DNA, on chromosome 6. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs7741021 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs7741021, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs7741021
- Position
- chr6:127147129
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Heel bone mineral density | — | β 0.083 | 2E-369 | PubMed |
| Heel bone mineral density | A | β 0.082 | 2E-140 | PubMed |
| Fracture | A | β 0.051 | 9E-65 | PubMed |
| Bone density Z-score | — | — | 2E-50 | PubMed |
| Bone density T-score | — | — | 2E-50 | PubMed |
| Bone mineral density mean | — | — | 1E-36 | PubMed |
| Bone properties (heel) | C | β 0.06 | 9E-21 | PubMed |
| Bone properties (heel) | C | β 0.06 | 1E-19 | PubMed |
| Cholesteryl esters in HDL (UKB data field 23418) | C | β 0.03 | 2E-12 | PubMed |
| Bone ultrasound measurement (broadband ultrasound attenuation) | C | β 0.08 | 5E-12 | PubMed |
| HDL cholesterol levels (UKB data field 23406) | C | β 0.029 | 1E-11 | PubMed |
| Osteoporosis, osteopenia and pathological fracture (PheCode 743) | A | β 0.052 | 4E-11 | PubMed |
| Ultradistal forearm bone mineral density | C | β 0.068 | 2E-10 | PubMed |
| Cholesteryl esters in medium HDL (UKB data field 23569) | C | β 0.028 | 3E-10 | PubMed |
| Cholesterol in medium HDL (UKB data field 23568) | C | β 0.027 | 7E-10 | PubMed |
| Phospholipid levels in HDL | A | β 0.022 | 2E-9 | PubMed |
| DXA-Bone mineral density (legs) (UKB data field 23231) | C | β 0.05 | 2E-9 | PubMed |
| Apolipoprotein A1 levels | A | β 0.021 | 3E-8 | PubMed |
| Bone properties (heel) | — | — | 4E-8 | PubMed |
| Bone ultrasound measurement (velocity of sound) | C | β 0.09 | 3E-7 | PubMed |
Sources
- dbSNP: rs7741021 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies